Keywords
Spirometry
Airways
Young adult
Public health
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Abstract
Objective: To evaluate spirometric changes in young users of electronic smoking devices (ESDs), with emphasis on forced expiratory flow between 25% and 75% of forced vital capacity (FEF25-75%) as an early marker of small airway dysfunction. Methods: This was an exploratory cross-sectional observational pilot study including 27 participants (experimental group: n=15; control group: n=12). Forced vital capacity (FVC), forced expiratory volume in one second (FEV1), and FEF25-75% were analyzed according to American Thoracic Society/European Respiratory Society guidelines. Statistical significance was set at 5%. Results: A significant reduction in FEF25-75% was observed in the experimental group compared to predicted values (p=0.0181). No significant differences were found for FVC and FEV1. Respiratory symptoms were more frequent among ESD users (66.7% vs. 0%; p<0.001). Conclusion: The findings suggest early functional changes in the small airways among users of electronic smoking devices (ESDs). FEF25–75% emerged as a potentially useful complementary parameter for identifying early peripheral airway functional alterations, highlighting the need for studies with larger sample sizes to confirm its clinical applicability.
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