Abstract
Objective: Perform an integrative literature review to analyze the complexity of the constituent biomarkers in the salivary fluid complex, demonstrating the health or disease status of an individual. Methods: As search strategy, searches were established in the PubMed/ MedLine, LiLacs and SciELo databases, in the period 2013-2019, combining the descriptors “the importance of salivary flow” and “saliva as a means of diagnosis and monitoring of eventual diseases”. Boolean descriptors in their respective research sources. Results: The application of saliva as a form of diagnosis in addition to monitoring possible pathologies has been employed in recent years because of its simple, economic and noninvasive form. These features make it a beneficial path when compared to blood and urine collection, facilitating early detection of certain early-stage diseases due to the presence of specific salivary biomarkers. Final Considerations: Saliva is a biological fluid found in the oral cavity that is very relevant in the physiological and pathological correlation that constitutes the human being. The benefit of its application as in laboratory tests establishes by the fact that its availability, less invasive, easy to collect, low cost being compared with other forms of diagnosis.