Abstract
Introduction: Systemic lupus erythematosus (SLE) is a chronic, multisystemic inflammatory disease of unknown cause and autoimmune in nature and evolves with polymorphic clinical manifestations, with periods of exacerbations and remissions. Systemic sclerosis (ES) is an autoimmune disease of unknown etiology that affects connective tissue. The concomitance of syndromes that affect the connective tissue is already known, since the manifestations are not always restricted to the characteristics of a single disease. Case report: A 47-year-old patient diagnosed with Systemic Lupus Erythematosus was regularly followed up when she started progressive dyspnea and dysphagia. She was admitted for clinical investigation and the presence of pulmonary fibrosis, in addition to esophagopathy, was observed on radiological imaging. The patient already had frequent episodes of Reynoud's phenomenon and sclerodactyly. With the evolution of the condition in association with the changes that the patient already had, the diagnosis of Systemic Sclerosis was closed in overlapping with the systemic lupus erythematosus. Discussion: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with a broad clinical and immunological spectrum. ES can affect several organs and systems, the skin being the organ most affected, followed by the lungs, musculoskeletal system, kidneys, heart and gastrointestinal tract. The overlapping of these pathologies is a rare case that demands the rapid identification of the health professional in order to minimize data and complications of both pathologies.