Abstract
Objective: To report the case and describe the challenges associated with Amyotrophic Lateral Sclerosis, analyzing its effects. Case Details: Amyotrophic Lateral Sclerosis (ALS) is a progressive, idiopathic and fatal neurodegenerative disease that affects motor neurons in the spinal cord, brain stem and motor cortex. In an attempt to understand the challenges faced by a patient with ALS, adjuvant therapies were evaluated to delay the progress of the disease, in addition to this study showing that the implantation of the diaphragmatic pacemaker strengthened the musculature, in which she obtained more force to perform respiratory movements, that the proportional reduction of Forced Vital Capacity (FVC) (46%) and Forced Expiratory Volume in the first minute (FEV1) (50%) became severe and that hematopoietic stem cell transplants obtained a improvement in strength for 6 months and in speech. Final Considerations: However, more studies and research should be carried out to better investigate the mechanisms of action of supporting therapies in the treatment of ALS with the combination of pharmacotherapy to increase survival and optimize their quality of life, in addition to helping in the search for new treatments.