Abstract
Introduction: Sickle cell anemia (SCA) is a genetic disease of great worldwide prevalence; caused by the presence of an anomalous form of hemoglobin, Hemoglobin S (HbS). Objective: to characterize the clinical profile of patients with sickle cell anemia accompanied at a pharmaceutical care unit in the city of Teresina - Piauí, using hydroxyurea (HU). Results: A significant decrease of the nominal and percentage values compared to the control, in the reticulocyte, total leukocyte and platelet values from the first trimester analyzed, was observed, and drop in the 5th trimester of Hemacic and hematocrit. Conclusion: the use of HU in patients with AF showed toxicity, with variations as a function of time.