Abstract
Objective: To describe the rare case of elevated CA 19-9 levels in the presence of Mirizzi Syndrome, a benign biliary tract disorder, unrelated to the presence of malignant disease. Case report: A 61-year-old woman was admitted to the emergency department with a history of abdominal pain in epigastrium, with irradiation to the right hypochondria and back, associated with episodes of nausea and vomiting, as well as jaundice with choluria and fecal acolia. During diagnostic investigation, CA 19-9 of 8,962U/mL, cholangio-resonance was performed, which showed an image suggestive of Mirizzi syndrome. Patient who underwent videolaparoscopic cholecystectomy associated with retrograde cholangiopancreatography with the passage of an intra-choledochal plastic drain, presenting intense drainage of biliary content to the duodenum. At follow-up, the patient remained uneventful or had evidence of malignant disease, with a reduction in serum CA 19-9 to 28.9U/mL after 12 weeks of surgery. Final considerations: Although uncommon, Mirizzi syndrome is one of the etiological possibilities for the elevation of tumor marker CA 19-9. It is a benign diagnosis for situations involving elevated cell surface carbohydrate antigen, which has its normalized reference value after surgical treatment of the obstructive process.