Abstract
Objective: To describe, through a systematic literature review, the main studies, news and influences of Sodium Glucose Cotransporter 2 (SGLT2) inhibitors on the cardiovascular system of type 2 diabetic patients. Methods: The BIREME database was used for research, considering texts with the descriptors “Sodium Glucose Transporter 2 Inhibitors” and “Cardiovascular Diseases”, published between the years of 2009-2019, written in English, Portuguese and Spanish, subsequently evaluated, interpreted and tabulated. Results: Initially, 277 articles were found in the research. After review 192 publications were discarded from the evaluation for not having evidenced the necessary inclusion criteria, and 85 publications were selected. Of these 85 articles that presented the selection criteria, 38 had restricted use and access to their journals subscribers. The remaining 47 texts were analyzed and chosen by the authors for review. Final considerations: It is concluded that the medications of SGLT2 inhibitors are shown to be a therapeutic option of great interest for type 2 diabetics, given their capacity to promote numerous beneficial systemic changes in those patients and directly influence the reduction of cardiovascular risk, reducing the mortality and heart failure hospitalizations rates.