Abstract
Objective: discuss, through a narrative review, the prevention of Non-alcoholic Fatty Liver Disease (NAFLD) complications in obese patients and present possibilities for therapeutic interventions. Literature Review: NAFLD represents a manifestation of obesity and the components of the metabolic syndrome, associated with a sedentary lifestyle and inappropriate eating habits, characterized by high caloric intake. The treatment consists mainly in lifestyle interventions based on dietary habits and exercises. The main therapeutic options described in literature are lifestyle changes, pharmacological therapy and bariatric surgery. Drug therapy is indicated for all patients because it reduces the progression of the disease. The drugs which had shown significant improve in fibrosis with high efficiency and long-term safety are pioglitazone e liraglutide, meanwhile most of other drugs maintain a lower level of evidence. Final considerations: the most efficient therapeutic management to NAFLD is based on proper diet and regular practice of exercises in a long-term basis.