Abstract
Objective: To provide a tool to assist health professionals in the medical clinic regarding treatments still under study to combat COVID-19 and serve as a basis for future studies. Methods: For the development of this systematic review, research was carried out on the Embase, Pubmed databases and on the website clinicaltrials.gov, with the following inclusion criteria: selection of clinical trials carried out in adults, randomized or not, who addressed the discussion on the treatment or development of vaccines for COVID-19. Of the articles found, 22 studies were selected and those with a different methodological design were excluded. Results: The studies cover clinical trials that are divided into double or triple blind and present a low risk of bias. Among the tested interventions, Hydroxychloroquine and antivirals are the drugs that show the most promise in controlling the disease. The final results, however, are not yet available, as studies are ongoing. Final considerations: There is still no scientific evidence to recommend the use of any of the tested drugs, making it necessary to continue and maintain ongoing studies.