Keywords
Covid-19
Sars-Cov-2
Reacciones adversas
Tratamiento
How to Cite
Copyright © | All rights reserved.
The journal holds the exclusive copyright for the publication of this article under the terms of Brazilian law 9610/98.
Partial reproduction
The use of parts of the texts, figures and questionnaire of the article is free, being mandatory the citation of the authors and journal.
Total reproduction
It is expressly prohibited and must be authorized by the journal.
Abstract
Objective: To review the scientific literature on the efficacy and safety of Hydroxychloroquine (HCQ) in the management of patients infected with the new coronavirus (SARS-CoV-2), control of viral transmission, adverses reations and possible use as prophylaxis. Literature review: direct antiviral effect and cytokine control were observed in vitro tests, improvement of symptoms and reduction of viral load in observational studies,in the milder conditions of the disease. However, divergences regarding the safety of treatment and the lack of randomized controlled trials so far, do not allow such a medicine to be used on a large scale, as they do not meet the rigor of the evaluation of scientific effectiveness. Final considerations: Large-scale trials with greater scientific impact are essential in order to better elucidate the efficacy and safety of HCQ, therefore caution has been recommended in the off-label use of this medication for patients with COVID-19, in order not to aggravate the health condition.