Abstract
Objective: The study aims to investigate the adverse event related to the high incidence of cerebral venous thrombosis in an endemic area of yellow fever. Methods: The incidence of 17 cases, over an interval of 5 months, with a clinical picture of intracranial hypertension was analyzed. The patients underwent brain imaging tests, showing signs of cerebral venous thrombosis (CVT). Results: The epidemiological evaluation revealed that 4 of the patients had risk factors for CVT, however 4 cases showed clinical and laboratory signs of aseptic meningitis. Direct or indirect exposure to the live attenuated virus of the yellow fever vaccine was observed in 16 patients. Serological investigation was carried out on 10 patients. Conclusion: The serological results were undetectable, however the collection time after the 8th day favors false negative results, and the clinical and epidemiological data are recommended to confirm the diagnosis. The indicated treatment was the use of anticoagulant with total recovery in 15 patients and the partial functional improvement observed in 2 cases.