Abstract
Objective: This present clinical case demonstrates an association between the stiff person syndrome (SPS) and diabetes mellitus 1 and Hashimoto hypothyroidism in a female pacient diagnosed when 35 years that presented an amazing response to benzodiazepine and significant improvement in her life’s quality. Case details: Stiff person syndrome is characterized by a huge axial and proximal members stiffness associated with spasms. There is a memorable immune component of this disease characterized by antibody anti-GAD. This present clinical case demonstrates an association between this syndrome and diabetes mellitus 1 and Hashimoto hypothyroidism in a female pacient diagnosed when 35 years that presented an amazing response to benzodiazepine and significant improvement in her life’s quality. Despite the fact that the disease is rare, it is a condition that deserves to be investigated in pacients who complain about muscles disease and polyiendocrinopathies to achieve correct diagnosis and treatment. Final considerations: Although it is a rare condition, it is a condition that deserves to be investigated in patients with muscle involvement and polyiendocrinopathies for diagnosis and appropriate treatments.