Abstract
Objective: To report a case of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) associated with allopurinol, since it is a rare clinical condition and is associated with high morbidity and mortality. Details of the case: A 69-year-old female patient, admitted to a tertiary hospital in the interior of São Paulo, with fever for 10 days and a diffuse rash all over her body associated with generalized pruritus. Laboratory tests showed eosinophilia and leukocytosis. He had been using the drug Allopurinol for three months. Treatment with corticotherapy was started, showing partial improvement of the rash. On the eighth day of hospitalization, the hypothesis of DRESS syndrome was made and the dose of prednisone was increased, with complete improvement of the condition. Skin biopsy showed mild and nonspecific histological findings. The patient was discharged with an outpatient referral for the purpose of weaning from corticosteroid therapy. Final considerations: Early recognition and treatment of the disease are essential to improve the prognosis of sick patients and consequently reduce the morbidity and mortality of the disease.