Abstract
Objective: To evaluate the effectiveness of applying botulinum toxin in the treatment of primary hyperhidrosis in its different sites of involvement. Methods: A meta-analysis was performed using the PubMed, Cochrane, Scopus, Scientific Electronic Library Online (SciELO) and Open Thesis databases. The keywords used were "primary hyperhidrosis", "treatment" and "botulinum toxin". Two reviewers performed independent protocols using a standard form, based on a pre-defined systematic review protocol, PRISMA. Results: The search protocol found 1096 articles in the initial selection, of which 14 studies were included. Homogeneity analysis showed a Cochran Test Q of 80.1242 (p=0.001) and a Higgins I² test of 96.24%. Symmetry was assessed by the asymmetry test of the funnel graph with a t-value of 2.9111 (p=0.0131). The data on adverse events were asymmetric and heterogeneous, justifying the use of the fixed effects model. Final Considerations: The use of botulinum toxin is safe and effective for the treatment of Primary Hyperhidrosis (Evidence Level 1b). Injections of toxins act as a palliative measure, promoting the cessation or reduction of sweat with an extremely variable duration of effect from 4 weeks to 6 months, and with few adverse effects.