Abstract
Objective: The objective of our work was to evaluate the effect of the use of copaiba ointment 20% in the recovery of traumatic injuries caused by minimally invasive procedures in the swine epidermis. Methods: Five female pigs with 60 days of age received topical application of Cobaíba ointment at a dose of 2mg per application on the left cervical side for 14 consecutive days, after dermo-abrasion. Dermo-abrasion was also performed on the right cervical side, but nothing was applied. On the 14th day, a biopsy was performed using a 5 mm punch, and the Copaiba ointment was applied for seven days followed by a new punch on the 21st. During 21 days, induration and tissue hyperemia were verified, and after biopsy, the samples were sent for histomorphological evaluation, differences were identified if P <0.05 between parameters measured on the side with or without Copaiba. Results: Differences were found only on the 21st day, between the number of blood vessels, inflammatory cells (eosinophils, neutrophils and plasma cells) and tissue fibrosis between the group treated with and without copaiba (P <0.01). Conclusion: Copaiba ointment has been shown to be beneficial in tissue healing in pigs with minimally invasive lesions.