Abstract
Objective: To describe the relationship of peripheral resistance of receptors to insulin as a promoter and prognosis in the development of Alzheimer's Disease (AD), as well as the new prophylactic drug trends that interrupt the progression of AD. Bibliographic Review: Insulin plays an important role as a growth factor and regulates the metabolism of glucose, fatty acids and proteins. Factors such as obesity, physical inactivity and a diet with a high fat and sugar content are strongly associated with insulin resistance and type 2 diabetes mellitus. In the brain, insulin acts in the growth and differentiation of neurons, participates in higher cognitive functions, in formation of long-term memory and has a neuroprotective effect. Final Considerations: Hyperglycemia, pro-inflammatory signal peptides, oxidative stress and interrupted brain insulin signaling are associated with the promotion and development and progression of AD. Insulin can be effectively delivered directly to the brain via the intranasal route that allows the hormone to overcome the blood-brain barrier and modulate central nerve functions.