Abstract
Objectives: To analyze the success of pharmacological treatment with a focus on the formation of nicotine for smoking cessation in patients followed up for at least 1 year after therapy. Methods: This is a literature review according to the PRISMA protocol. With the initial selection of 748 articles, 5 articles were selected, after final screening, which were evaluated using the “Cochrane risk of Bias” and using the GRADE quality evidence system to measure the quality of the articles. Results: The selected articles represent the randomized clinical trials that use the result of nicotine for smoking cessation, an analysis of the trials, that there is no statistical difference in the effectiveness of the treatment between the different forms of nicotine when compared to the traditional treatment already well established in the literature, taking into account the abstinence rates after 1 year of smoking cessation. Final considerations: Nicotine conversion is effective in smoking cessation after 1 year of treatment regardless of the partnership method.