Abstract
Objective: The aim of the current study was to review the epidemiology, the etiology and the management of cleft lip and/or palate (CLP). Literature review: CLP are among the most common congenital anomalies affecting the head and neck. The etiology of FLP is complex and multifactorial and includes genetic susceptibility and environmental risk factors. Clinically, the patients may have problems with speech, feeding, impaired hearing and difficulties in social interaction. Interdisciplinary and specialized treatment is recommended, from birth to adulthood. Final considerations: FLP is a lifelong condition and may lead to problems beyond the craniofacial complex. Despite current advances in the knowledge on CLP, some issues remain unclear, such as the comorbidities not directly related to the malformation and the longer-term impact of CLP. Researching on CLP, early interdisciplinary evaluation, and long-term follow-up of patients with orofacial clefting are essential to achieving optimal clinical outcomes.