Abstract
Objective: To analyze the main side effects of the standard drug regimen, polychemotherapy, used in the treatment of leprosy. Methods: This is a descriptive cross-sectional study, conducted with 40 participants, attended at the Dermatology Clinic of the University of the State of Pará. The researchers used an adaptation of the Form for Investigation of the Occurrence of Adverse Effects in Polychemotherapy (PQT) in leprosy, with variables grouped into social, dermatological, laboratory and reaction profiles. Results: Most patients were: men, over 60 years of age, retired, with only elementary education. As for the clinical classification, predominantly, the dimorphic and multibacillary form, in 12 months of treatment. The organic systems most closely related to adverse reactions were: excretory, nervous, cutaneous and respiratory, especially through the use of dapsone. Among the adverse effects, nausea (32.50%) in the use of rifampicin, myalgia (65%) in the use of dapsone and skin hyperpigmentation (77.50%) in the use of clofazimine stands out. Conclusion: The present study demonstrated that the most frequent adverse reactions were mild and are associated with the use of dapsone and clofazimine, and the early detection of these effects is extremely important for the effective intervention of serious events.