Abstract
Objective: To carry out an integrative review of the cellular and molecular effects of low-intensity laser therapy (LLL) in dental procedures. Methods: The descriptors "Inflammation Mediators", "Low-Level Light Therapy", "Dentistry", "Biomarkers", "Clinical Trial", "Drug Evaluation" and "Preclinical" were applied to the Online Search and Analysis of Medical Literature System (MEDLINE) via National Library of Medicine (PubMed), Science Direct and Google Scholar, linked through “AND/OR”. The 10-year period (2011 to 2021) was used and a total of 130 studies were found, which after analysis only 15 were included. Results: The literature shows this therapy as promising for several problems that affect the oral cavity, providing regenerative effects in the healing process, anti-inflammatory effects, reduction of pain conditions, also playing an extremely important role in the modulation of cytokines and factors of cell growth in dental procedures. The levels of interleukin 1 (IL-1β) were variable in association with LLLT, the levels of substances P and matrix metalloproteinase-8 (MMP-8) were reduced in the groups evaluated. Final considerations: LLLT can promote positive clinical responses in dentistry due to the action of mediators involved in these regenerative processes, however, due to the scarcity of studies in some fields of dentistry, further research is needed in the area.