Abstract
Objective: This article sought to analyze the behavior of oxidative stress and the serum expression of creatine kinase in patients with chronic obstructive pulmonary disease participating in a pulmonary rehabilitation program. Methods: This is a study analytical, longitudinal, prospective and quantitative clinical trial, approved by the Research Ethics Committee (nº 1.965.332). Six volunteers, with a mean age of 67.8, underwent spirometry and blood analysis to read creatine kinase and oxidative stress, before the 1st session (T0) and after the 20th session (T20) of the Pulmonary Rehabilitation protocol. The analysis of variance test (ANOVA) was used to compare the means between the two testing moments using the BioEstat 5.0 software with p ≤0.05. Results: There was a significant response of muscle proteolysis markers (CK-MB; p = 0.026) and (CK-NAC; p = 0.017) and not significant for the biochemical analysis of oxidative stress (Catalase; p = 0.764) and (Lipid peroxidase; p = 0.584) when comparing the times T0 and T20. Conclusion: There was a positive impact on serum creatine kinase expression in patients with chronic obstructive pulmonary disease while conducting a pulmonary rehabilitation protocol. impact on serum creatine kinase expression in patients with chronic obstructive pulmonary disease while conducting a pulmonary rehabilitation protocol.