Abstract
Objective: To describe the knowledge about drug therapies to treat women who have infertility because of Polycystic Ovary Syndrome (PCOS). Bibliographic review: Letrozole is the first-line drug for inducing ovulation in the treatment of women with PCOS. Clomiphene citrate is reserved for cases where there is no possibility of using letrozole as a first line. The combination of metformin is recommended in cases of insulin resistance associated with PCOS or poor response to ovulation inducers. Regarding the use of gonadotropins that induce ovulation, there is evidence of higher rates of clinical pregnancy, ongoing pregnancy and live births of ovulation induction with gonadotropins when compared to CC, however, due to its higher cost, and greater risk of ovarian hyperstimulation this medication is used as a second-line treatment. Another therapeutic option would be the use of myo-inositol but the evidence is of low quality. Finally, in vitro fertilization is also part of the treatment, but the articles demonstrate that only if previous treatments do not work. Final considerations: The treatment of PCOS is multifactorial, and there is no single treatment for all patients. Further studies are needed.