Abstract
Objective: To evaluate the presence of polypharmacy and drug interactions between hypertensive and diabetic patients in a health unit in the state of Pará. Methods: This study was divided into two stages: the first consisted of the application of a questionnaire, evaluating sociodemographic, clinical and polypharmacy information; in the second, the presence of drug interactions through the Drug Interaction Checker system was detected. Results: The study included 101 hypertensive and/or diabetic patients treated at the Basic Health Unit in the state of Pará. Most were female patients (69.3%), aged 60 years or older (67.3%) and with income less than or equal to a minimum wage (51.5%). 41.6% (n=42) practiced the use of 5 or more medications. Drug interactions were identified in 76% of patients seen (n=77) and in 24% (n=24) no interactions were identified. The Drug Interaction Checker program identified 237 types of drug interactions, 7% severe, 72% moderate and 21% mild. Conclusion: The need for guidance to patients accompanied by chronic diseases is emphasized due to the complexity of the treatment and the high probability of occurrence of drug interactions.