Abstract
Objective: Approach scientific associations established until this moment about Kawasaki disease and Multisystem Inflammatory Syndrome associated with COVID-19 in pediatric patients. Bibliographic review: Kawasaki disease (KD) and Multisystem Inflammatory Syndrome (MISC) have similarities when the topic is clinic and laboratory aspects. Suspicious cases of DK in pediatrics patients with Sars-CoV-2 were confirmed as MISC afterwards, demonstrating the importance of all professionals of health to knowing the differences between both diseases, which determines different conducts. Thus, it’s important to highlight the main complications arising from the two diseases and warn about the consequences of these complications for health, as shock in need of support with inotropics; myocarditis and heart failure, usually requiring respiratory support and vasopressor amines. It’s necessary to give a diagnosis and a treatment at the right moment for a better prognosis, avoiding further complications of both diseases in children and adolescents. Final considerations: This article aims to differentiate SIM-P from KD, so that it is possible to direct the therapy and the correct conduct for each disease, providing better prognosis.