Abstract
Case detail: Newborn female, gestational age of 33 weeks, admitted to the neonatal intensive care unit due to hyaline membrane syndrome. It evolved with sepsis, necessitating antibiotic therapy and installation of a central venous catheter in the right upper limb. After persistence of sepsis, an echocardiogram was performed, which showed a right atrial thrombus image of probable septic etiology, pedunculated, mobile, adhered to the atrial septum. Patient was submitted to thrombolysis and evolved with clinical improvement and outpatient follow-up after discharge. Discussion: The persistence of septic syndrome in newborns leads to the suspicion of septic thrombi, especially when there is a central venous catheter, which is considered the greatest risk factor. The diagnosis is preferably made through echocardiogram or contrast arteriography and the treatment consists of catheter withdrawal and thrombolytic therapy.