Resumen
Objetivo: Describir las características clínicas y epidemiológicas de los pacientes hospitalizados por Covid-19 en un hospital público de Minas Gerais. Métodos: Se trata de un estudio observacional, transversal, basado en la historia clínica electrónica. La población estuvo constituida por pacientes con confirmación de laboratorio para Covid-19 entre marzo de 2020 y marzo de 2021. Se analizaron datos demográficos, manifestaciones clínicas y comorbilidades. Resultados: Se incluyeron 92 pacientes con diagnóstico de Covid-19. La mayoría de los pacientes eran hombres (62,0%), con una edad media de 58 años. Las comorbilidades más prevalentes fueron hipertensión arterial (40,2%), diabetes (21,7%) y cardiopatías (9,8%). Los síntomas más frecuentes fueron disnea (64,1%), fiebre (48,9%) y tos seca (42,4%). Treinta y siete pacientes (40,2%) requirieron atención en Unidad de cuidados intensivos (UCI), y de estos, solo uno no recibió soporte ventilatorio invasivo. La tasa de mortalidad en la institución de investigación fue del 33,7%. Conclusión: De acuerdo con los datos, se observó que la mayoría de las personas infectadas por Covid-19 eran del sexo masculino, con una edad promedio de 58 años y con al menos una enfermedad de base. Los síntomas más prevalentes fueron disnea, fiebre y tos seca.
Referencias
AHN DG, et al. Current Status of Epidemiology, Diagnosis, Therapeutics, and Vaccines for Novel Coronavirus Disease 2019 (COVID-19). J. Microbiol. Biotechnol., 2020; 30: 313-324.
AKULA SM, MCCUBREY JA. Where are we with understanding of COVID-19?. Adv Biol Regul., 2020; 78: 100738.
ATZRODT CL, et al. A Guide to COVID‐19: a global pandemic caused by the novel coronavirus SARS‐CoV‐2. FEBS J., 2020; 287(17): 3633-3650.
BHATRAJU PK, et al. Covid-19 in Critically Ill Patients in the Seattle Region — Case Series. N Engl J Med., 2020: NEJMoa2004500.
BRASIL. Protocolo de Manejo Clínico da Covid-19 na Atenção Especializada. 2020. Disponível em: https://bvsms.saude.gov.br/bvs/publicacoes/manejo_clinico_covid-19_atencao_especializada.pdf. Acessado em: 22 de janeiro de 2022.
CENTERS FOR DISEASE CONTROL AND PREVENTION. COVID-19 Overview and Infection Prevention and Control Priorities in non-U.S. Healthcare Settings. 2021. Disponível em: https://www.cdc.gov/coronavirus/2019-ncov/hcp/non-us settings/overview/index.html. Acessado em: 21 de março de 2021.
CHAND S, et al. COVID-19-Associated Critical Illness—Report of the First 300 Patients Admitted to Intensive Care Units at a New York City Medical Center. Journal of Intensive Care Medicine, 2020; 35(10): 963-970.
CHEN N, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet, 2020; 395(10223): 507–513.
CHEN Y, et al. Aging in COVID-19: Vulnerability, immunity and intervention. Ageing Res Rev., 2021; 65: 101205.
CHEN Z, et al. Clinical Characteristics of Patients with Severe and Critical COVID-19 in Wuhan: A Single-Center, Retrospective Study. Infect Dis Ther., 2021; 10(1): 421-438.
CHOI A, et al. Serum Neutralizing Activity of mRNA-1273 against SARS-CoV-2 Variants. Journal of Virology, 2021; 95(23): e01313-21.
CORRÊA TD, et al. Clinical characteristics and outcomes of COVID-19 patients admitted to the intensive care unit during the first year of the pandemic in Brazil: a single center retrospective cohort study. Einstein (São Paulo), 2021; 19: 1-10.
FERRANDO C, et al. Características, evolución clínica y factores associados a la mortalidad en UCI de los pacientes críticos infectados por SARS-CoV-2 en Espana: ˜ estúdio prospectivo, de cohorte y multicêntrico. Rev Esp Anestesiol Reanim., 2020; 67(8): 425-437.
GANDHI RT, et al. Mild or Moderate Covid-19. N Engl J Med., 2020; 383: 1757-1766.
GRASSELLI G, et al. Baseline Characteristics and Outcomes of 1591 Patients Infected with SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy. JAMA, 2020; 323(16): 1574–1581.
HANG JJ, et al. Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China. Allergy, 2020; 75: 1730–1741.
HE F, et al. Coronavirus disease 2019: What we know?. J Med Virol., 2020; 92(7): 719-725.
HOSOKI K, et al. Molecular mechanisms and epidemiology of COVID-19 from an allergist’s perspective. J Allergy Clin Immunol., 2020; 146(2): 285-299.
ISER BPM, et al. Definição de caso suspeito da COVID-19: uma revisão narrativa dos sinais e sintomas mais frequentes entre os casos confirmados. Epidemiol. Serv. Saúde, 2020; 29(3): e2019354.
JAILLON S, et al. Sexual Dimorphism in Innate Immunity. Clinical Reviews in Allergy & Immunology, 2019; 56: 308–321.
JIN Y, et al. Virology, Epidemiology, Pathogenesis, and Control of COVID-19. Viruses, 2020; 12: 372.
KHALAF K, et al. SARS-CoV-2: Pathogenesis, and Advancements in Diagnostics and Treatment. Front Immunol., 2020; 11: 1-20.
KHAN M, et al. Epidemiological and clinical characteristics of coronavirus disease (COVID-19) cases at a screening clinic during the early outbreak period: a single-centre study. J Med Microbiol., 2020; 69(8): 1114–1123.
LI X, et al. Clinical characteristics of 25 death cases with COVID-19: A retrospective review of medical records in a single medical center, Wuhan, China. International Journal of Infectious Diseases, 2020; 94: 128–132.
MACIEL EL, et al. Fatores associados ao óbito hospitalar por COVID-19 no Espírito Santo. Epidemiol. Serv. Saúde, 2020; 29: 4.
MATSUNAGA N, et al. Clinical Epidemiology of Hospitalized Patients With Coronavirus Disease 2019 (COVID-19) in Japan: Report of the COVID-19 Registry Japan. Clin Infect Dis., 2021; 73(11): e3677–e3689.
PAPANIKOLAOU V, et al. From delta to Omicron: S1-RBD/S2 mutation/deletion equilibrium in SARS-CoV-2 defined variants. Gene, 2022; 814: 146134.
PONTES L, et al. Perfil clínico e fatores associados ao óbito de pacientes COVID-19 nos primeiros meses da pandemia. Esc Anna Nery, 2022; 26: e20210203.
SHEERVALILOU R, et al. COVID‐19 under spotlight: A close look at the origin, transmission, diagnosis, and treatment of the 2019‐nCoV disease. J Cell Physiol., 2020; 235: 8873–8924.
SHEPHERD R, et al. Sexual Dimorphism in Innate Immunity: The Role of Sex Hormones and Epigenetics. Front. Immunol., 2021; 11604000.
SULEYMAN G, et al. Clinical Characteristics and Morbidity Associated With Coronavirus Disease 2019 in a Series of Patients in Metropolitan Detroit. JAMA Network Open. 2020; 3(6): e2012270.
TEICH VD, et al. Características epidemiológicas e clínicas dos pacientes com COVID-19 no Brasil. Einstein (São Paulo), 2020; 18: 1-7.
TREVISOL FS, et al. Assessment of patients with Covid-19 hospitalized in southern Santa Catarina. Rev. Soc. Bras. Med. Trop., 2020; 53: e20200579.
WANG D, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020; 323(11): 1061-1069.
WANG H, et al. The genetic sequence, origin, and diagnosis of SARS-CoV-2. Eur J Clin Microbiol Infect Dis., 2020; 39(9):1629-1635.
WORD HEALTH ORGANIZATION. WHO Coronavirus (COVID-19) Dashboard. 2022. Disponível em: https://covid19.who.int/. Acessado em: 3 de março de 2022.
XIE J, et al. Characteristics of patients with coronavirus disease (COVID‐19) confirmed using an IgM‐IgG antibody test. J Med Virol., 2020; 92: 2004–2010.
YANG X, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med., 2020; 8(5): 475–481.
YI C, et al. Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies. Cell Mol Immunol., 2020; 17(6): 621-630.
YUAN M, et al. A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV. Science, 2020; 368: 630–633.
