Palabras clave
Microcefalia
Toxicidad
Salud Ambiental
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Resumen
Objetivo: Este estudio tuvo como objetivo evaluar los estudios sobre la toxicidad del piriproxifeno en modelos animales de pez cebra y murino y su relación con la microcefalia. Métodos: Se utilizaron las palabras clave piriproxifeno y toxicidad para la búsqueda en las plataformas Pubmed, Scorpus, ScieLo y ScienceDirect. Se seleccionaron los artículos que utilizaron las palabras clave en el título o resumen. Los criterios de inclusión fueron: artículos en inglés o portugués que describieran un estudio experimental in vivo o in vitro con pez cebra (Danio rerio) y ratones. La información extraída fue el año de publicación, país, modelo animal y resultados de toxicidad. Resultados: 13 artículos fueron seleccionados. La exposición a una concentración de aplicación superior a la recomendada es tóxica. No se observó evidencia de microcefalia. Observamos un aumento en el número de publicaciones después de la epidemia, el país con mayor número de publicaciones fue Brasil y el pez cebra fue el modelo más utilizado. Consideraciones finales: Con base en los estudios, el piriproxifeno no está relacionado como causa de microcefalia, sin embargo provoca efectos tóxicos. Dado el amplio uso de este larvicida en los programas de control de arbovirus, recomendamos su uso con precaución.
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