Resumen
Objetivo: Este artículo tiene como objetivo reportar un caso de cáncer de mama en un paciente masculino, quien además presentaba síndrome de lisis tumoral y sospecha de metástasis en cráneo. Detalles del caso: El presente estudio reporta el caso de un paciente masculino, de 77 años, sin antecedentes familiares de cáncer, que presentó ginecomastia y masa irregular en región infraaxilar, con degeneración quística central, clasificada como BIRADS IV-A. El paciente evolucionó con síndrome de lisis tumoral y múltiples lesiones líticas óseas diseminadas por el cráneo, con posibilidad de afectación neoplásica secundaria. Consideraciones finales: El cáncer de mama en los hombres generalmente se diagnostica en etapas posteriores y generalmente se trata de acuerdo con los procedimientos recomendados para el cáncer de mama femenino. Es importante comprender la enfermedad y sus manifestaciones clínicas, así como generar conciencia sobre este tipo de cáncer en los hombres. Además, se necesitan más estudios sobre opciones terapéuticas específicas para el cáncer de mama masculino con el fin de establecer un estándar de atención basado en la evidencia para esta población.
Referencias
ABDELWAHAB YOUSEF AJ. Male Breast Cancer: Epidemiology and Risk Factors. Seminars in Oncology, 2017; 44(4): 267–272.
AMERICAN CANCER SOCIETY. 2023. Cancer Facts & Figures 2023. Disponível em: https://www.cancer.org/research/cancer-facts-statistics/all-cancer-facts-figures/2023-cancer-facts-figures.html. Acessado em: 26 de março de 2023.
ARAUJO SEA, et al. Impact of COVID-19 pandemic on care of oncological patients: experience of a cancer center in a Latin American pandemic epicenter. Einstein (Sao Paulo), 2020; 19: eAO6282.
BARBAR T, JAFFER SATHICK I. Tumor Lysis Syndrome. Advances in Chronic Kidney Disease, 2021; 28(5): 438- 446.e1.
BOZOVICH GE, et al. Daño colateral de la pandemia por COVID-19 en centros privados de salud de Argentina. Medicina (B. Aires), 2020; 80(3): 37–41.
BRINTON LA, et al. Prospective Evaluation of Risk Factors for Male Breast Cancer. JNCI Journal of the National Cancer Institute, 2008; 100(20): 1477–1481.
CARVALHO HDEA, et al. Impact of COVID-19 pandemic on a daily-based outpatient treatment routine: experience of a radiotherapy department of a tertiary public/university hospital in Brazil. Clinics (Sao Paulo, Brazil), 2020; 75: e2298.
DALY MB, et al. Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. Journal of the National Comprehensive Cancer Network: JNCCN, 2021; 19(1): 77–102.
DING YC, et al. Mutations in BRCA2 and PALB2 in male breast cancer cases from the United States. Breast Cancer Research and Treatment, 2011; 126(3): 771–778.
EL OMARI-ALAOUI H, et al. Male breast cancer. A report of 71 cases. Cancer Radiotherapie: Journal De La Societe Francaise De Radiotherapie Oncologique, 2002; 6(6): 349–351.
ELBACHIRI M, et al. Cancer du sein chez l’homme: à propos de 40 cas et revue de la littérature. The Pan African Medical Journal, 2017; 28: 287.
EXPERT PANEL ON BREAST IMAGING, et al. ACR Appropriateness Criteria® Evaluation of the Symptomatic Male Breast. Journal of the American College of Radiology: JACR, 2018; 15(11S): S313–S320.
FARIA RA, et al. Carcinoma de mama masculino: um relato de caso / Male breast carcinoma: a case report. Brazilian Journal of Health Review, 2020; 3(1): 78–95.
FELETTO E, et al. How has COVID-19 impacted cancer screening? Adaptation of services and the future outlook in Australia. Public Health Research & Practice, 2020; 30(4): 3042026.
GILBERT SF, et al. Clinical profile, BRCA2 expression, and the androgen receptor CAG repeat region in Egyptian and Moroccan male breast cancer patients. Breast Disease, 2011; 33(1): 17–26.
GUCALP A, et al. Male breast cancer: a disease distinct from female breast cancer. Breast Cancer Research and Treatment, 2019; 173(1): 37–48.
HANDY C, et al. Tumor lysis Syndrome in a Patient with Metastatic Breast Cancer Treated with Alpelisib. Breast Cancer: Basic and Clinical Research, 2021; 15: 11782234211037420.
HASSETT MJ, et al. Management of Male Breast Cancer: ASCO Guideline. Journal of Clinical Oncology, 2020; 38(16): 1849–1863.
INSTITUTO NACIONAL DE CÂNCER. Estimativa 2023: incidência de câncer no Brasil. 2022. Disponível em: https://www.inca.gov.br/publicacoes/livros/estimativa-2023-incidencia-de-cancer-no-brasil. Acessado em: 26 de março de 2023.
KAKHKI VRD, et al. Pattern and distribution of bone metastases in common malignant tumors. Nuclear Medicine Review. Central & Eastern Europe, 2013; 16(2): 66–69.
KHAN NAJ, TIRONA M. An updated review of epidemiology, risk factors, and management of male breast cancer. Medical Oncology, 2021; 38(4): 39.
KONDURI S, et al. Epidemiology of male breast cancer. The Breast: Official Journal of the European Society of Mastology, 2020; 54: 8–14.
MAKDISSI FBA, et al. An introduction to male breast cancer for urologists: epidemiology, diagnosis, principles of treatment, and special situations. International Brazilian Journal of Urology: Official Journal of the Brazilian Society of Urology, 2022; 48(5): 760–770.
METHAMEM M, et al. Breast cancer in men: a serie of 45 cases and literature review. The Pan African Medical Journal, 2020; 36: 183.
NOFAL MN, YOUSEF AJ. The diagnosis of male breast cancer. The Netherlands Journal of Medicine, 2019; 77(10): 356-359.
PEREIRA CU, MELO MS. Metástases cranianas: considerações sobre 21 casos. Arq Bras Neurocir, 2009; 28(3): 97-102.
RUDDY KJ, WINER EP. Male breast cancer: risk factors, biology, diagnosis, treatment, and survivorship. Annals of Oncology: Official Journal of the European Society for Medical Oncology, 2013; 24(6): 1434–1443.
SERDY K M, et al. Male Breast Cancer: A Single-Institution Clinicopathologic and Immunohistochemical Study. American Journal of Clinical Pathology, 2017; 147(1): 110–119.
SKLARIN NT, MARKHAM M. Spontaneous Recurrent Tumor Lysis Syndrome in Breast Cancer: American Journal of Clinical Oncology, 1995; 18(1): 71–73.
STARK AM, et al. Skull metastases: clinical features, differential diagnosis, and review of the literature. Surgical Neurology, 2003; 60(3): 219–225.
ZAJĄCZKOWSKA R, et al. Bone Pain in Cancer Patients: Mechanisms and Current Treatment. International Journal of Molecular Sciences, 2019; 20(23): 6047.
ZEHR KR. Diagnosis and Treatment of Breast Cancer in Men. Radiologic Technology, 2019; 91(1): 51M-61M.
