Google Académico | Citações: 16429 | índice h: 32 | índice i10: 482
El uso y no uso de medicamentos durante el embarazo: potenciales factores de riesgo para el desarrollo de malformaciones congénitas
PDF (inglés)

Palabras clave

Mujeres Embarazadas
Adherencia a la Medicación
Teratógenos
Anomalías Congénitas
Anomalías Inducidas por Medicamentos

Cómo citar

El uso y no uso de medicamentos durante el embarazo: potenciales factores de riesgo para el desarrollo de malformaciones congénitas. (2024). Revista Eletrônica Acervo Saúde, 24(8), e15221. https://doi.org/10.25248/reas.e15221.2024

Copyright © | Todos los derechos reservados.

La revista posee los derechos de autor exclusivos para la publicación de este artículo en los términos de la ley brasileña 9610/98.

Reproducción parcial
El uso de partes de los textos, figuras y cuestionario del artículo es libre, siendo obligatoria la citación de los autores y revista.

Reproducción total
Está expresamente prohibido y debe ser autorizado por la revista.

Resumen

Objetivo: Conocer el comportamiento de las mujeres del estado de Roraima en relación al uso de medicamentos durante el embarazo. Métodos: Encuesta mediante ficha epidemiológica. Resultados: Del total de 158 participantes, 37,3% dieron a luz niños con malformaciones congénitas y 62,7% no. La edad media (p=0,0380) junto con la renta familiar baja (p=0,0259) entre los grupos fue estadísticamente significativa, siendo las mujeres de 13 a 25 años (p=0,0006) las que tenían mayor riesgo de tener hijos con anomalías congénitas. Además, la falta de adherencia materna al tratamiento farmacológico (p=0,0260; OR: 2,727; IC: 1,156-6,434) también se asoció al desarrollo de estas anomalías. Además, el uso de analgésicos (p=0,0577; OR: 3,725; IC: 1,070-12,975) y antibióticos (p=0,0588; OR: 2,259; IC: 1,009-5,057) antes y durante el período gestacional parece favorecer la aparición de malformaciones congénitas. Conclusión: Las mujeres de 13 a 25 años, con ingresos inferiores o iguales a un salario mínimo y que no utilizan medicamentos prescritos durante el embarazo, están asociadas al desarrollo de niños con malformaciones congénitas. Además, el uso de analgésicos y antibióticos antes y durante el período gestacional parece favorecer la aparición de estas anomalías.

PDF (inglés)

Referencias

ANDERSEN JT, et al. Trimethoprim use prior to pregnancy and the risk of congenital malformation: a register-based nationwide cohort study. Obstetrics and Gynecology International, 2013; 2013: 1-9.

ATRASH HK, et al. Preconception care for improving perinatal outcomes: the time to act. Maternal and Child Health Journal, 2006; 10: S3-S11.

BRANNON PM e TAYLOR CL. Iron supplementation during pregnancy and infancy: uncertainties and implications for research and policy. Nutrients, 2017; 9: 1327.

BRONBERG R. Birth prevalence of congenital anomalies in the City of Buenos Aires, Argentina, according to socioeconomic level. Journal of Community Genetics, 2020; 11: 303-311.

CABRAL RD, et al. Antimicrobianos. In: Manual de teratogênese em humanos. Federação Brasileira das Associações de Ginecologia e Obstetrícia (FEBRASGO); 2011; 45-56.

CARMO TA, NITRINI SMOO. Prescrições de medicamentos para gestantes: um estudo farmacoepidemiológico. Cadernos de Saúde Pública, 2004; 20: 1004-1013.

DEAN JH, et al. Neural tube defects and associated anomalies before and after folic acid fortification. The Journal of Pediatrics, 2020; 226: 186-194.

DONG J, et al. Initiation and duration of folic acid supplementation in preventing congenital malformations. BMC Medicine, 2023; 21: 1-13.

EMORDI VC, OSIFO DO. Challenges of congenital malformations: an African perspective. Annals of Pediatric Surgery, 2018; 14: 1-7.

FLEMING TP, et al. Environmental exposures around conception: developmental pathways leading to lifetime disease risk. International Journal of Environmental Research and Public Health, 2021; 18: 1-18.

FONTOURA FC, CARDOSO MVLML. Association between congenital malformation and neonatal and maternal variables in neonatal units of a Northeast Brazilian city. Texto & Contexto – Enfermagem, 2014; 23: 907-914.

FRANÇA VH, et al. A multiprofessional perspective on the principal barriers to universal health coverage and universal access to health in extremely poor territories: the contributions of nursing. Revista Latino-Americana de Enfermagem, 2016; 24: e2795.

GILL SK, et al. Association between maternal age and birth defects of unknown etiology - United States, 1997-2007. Birth Defects Research Part A: Clinical and Molecular Teratology. 2012; 94: 1010-1018.

GREEN NS. Folic acid supplementation and prevention of birth defects. Journal of Nutrition, 2002; 132: 2356S-2360S.

HAN JY, et al. Unintended pregnancies and exposure to potential human teratogens. Birth Defects Research Part A: Clinical and Molecular Teratology, 2005; 73: 245-248.

HOWSON CP, et al. Controlling birth defects: reducing the hidden toll of dying and disabled children in low-income countries. Disease Control Priorities Project, 2008.

JOHNSON K, et al. Centers for disease control and prevention. Recommendations to improve preconception health and health care - United States/A report of the CDC/ATSDR preconception care work group and the select panel on preconception care. MMWR 2006; 55: RR-6.

KAPAPA M, et al. Risk factors for abdominal wall defects. Congenital Anomalies, 2020; 60: 54-61.

KARAI A, et al. Adverse perinatal outcome in teenage pregnancies: an analysis of a 5-year period in Southeastern Hungary. The Journal of Maternal-Fetal & Neonatal Medicine, 2019; 32: 2376-2379.

KANG G, et al. Adverse effects of young maternal age on neonatal outcomes. Singapore Medical Journal, 2015; 56: 157-163.

MASHUDA F, et al. Pattern and factors associated with congenital anomalies among young infants admitted at Bugando medical centre, Mwanza, Tanzania. BMC Research Notes, 2014; 7: 195.

MALVASI A, et al. Possible long term teratogenic effect of isotretinoin in pregnancy. European Review for Medical and Pharmacological Sciences, 2009; 13: 393-396.

MARIO DN, et al. Qualidade do pré-natal no Brasil: pesquisa nacional de saúde 2013. Ciência & Saúde Coletiva, 2019; 24: 1223-1232.

MEANS RT. Iron deficiency and iron deficiency anemia: implications and impact in pregnancy, fetal development, and early childhood parameters. Nutrients, 2020; 12: 447.

MEDAWAR G, et al. Awareness and use of folic acid among women of childbearing age. Annals of Global Health, 2019; 85: 1-6.

MOORE KL, et al. Embriologia básica. 9 ed. Rio de Janeiro: Elsevier, 2016. 311p.

NOGUEIRA-DE-ALMEIDA CA, et al. Além da nutrição – o impacto da nutrição materna na saúde das futuras gerações. 1ª ed. São Paulo: Luiz Martins Editorial Ltda., 2019; 180p.

NORDENG H, et al. Perception of risk regarding the use of medications and other exposures during pregnancy. European Journal of Clinical Pharmacology, 2010; 66: 207-214.

OBEID R, et al. Folate supplementation for prevention of congenital heart defects and low birth weight: an update. Cardiovascular Diagnosis and Therapy, 2019; 9: S424-S43.

PRICE HR, COLLIER AC. Analgesics in pregnancy: an update on use, safety and pharmacokinetic changes in drug disposition. Current Pharmaceutical Design, 2017; 23: 6098-6114.

SILVA LKP, MARQUES AEF. Utilização de medicamentos por gestantes: uma revisão sistemática da literatura. Revista de Atenção à Saúde, 2019; 17: 90-97.

SITKIN N, et al. Congenital anomalies in low- and middle-income countries: the unborn child of global surgery. World Journal of Surgery, 2015; 39: 36-40.

SNIJDER CA, et al. Intrauterine exposure to mild analgesics during pregnancy and the occurrence of cryptorchidism and hypospadia in the offspring: the generation r study. Human Reproduction, 2012; 27: 1191-1201.

TOMASI E, et al. Qualidade da atenção pré-natal na rede básica de saúde do Brasil: indicadores e desigualdades sociais. Cadernos de Saúde Pública, 2017; 33: e00195815.

VARGESSON N. Review thalidomide-induced teratogenesis: history and mechanisms. Birth Defects Research Part C, 2015; 105: 140-156.

VERMA RP. Evaluation and risk assessment of congenital anomalies in neonates. Children, 2021; 8:1-12.

VIELLAS EF, et al. Assistência pré-natal no Brasil. Cadernos de Saúde Pública, 2014; 30: S85-S100.

WANDERLEY HYC, ARTIGALÁS OAP. Analgésicos e anti-inflamatórios. In: Manual de teratogênese em humanos. Federação Brasileira das Associações de Ginecologia e Obstetrícia (FEBRASGO); 2011; 95-103.

WANG D, et al. Maternal periconceptional folic acid supplementation and risk for fetal congenital heart defects. The Journal of Pediatrics, 2022; 240: 72-78.

WILSON RD, et al. Pre-conception folic acid and multivitamin supplementation for the primary and secondary prevention of neural tube defects and other folic acid-sensitive congenital anomalies. Journal of Obstetrics and Gynaecology Canada, 2015; 37: 534-549.

WU VK, et al. Burden of surgical congenital anomalies in Kenya: a population-based study. Journal of Tropical Pediatrics, 2013; 59: 195-202.

ZHANG XH, et al. Chromosomal abnormalities: subgroup analysis by maternal age and perinatal features in zhejiang province of China, 2011–2015. Italian Journal of Pediatrics, 2017; 43: 1-6.