Palabras clave
terapia con fagos
péptidos antimicrobianos
compuestos organometálicos
Cómo citar
Copyright © | Todos los derechos reservados.
La revista posee los derechos de autor exclusivos para la publicación de este artículo en los términos de la ley brasileña 9610/98.
Reproducción parcial
El uso de partes de los textos, figuras y cuestionario del artículo es libre, siendo obligatoria la citación de los autores y revista.
Reproducción total
Está expresamente prohibido y debe ser autorizado por la revista.
Resumen
Objetivo: Abordar el desafío global en salud pública y alternativas que estamos desenvolvidas no combatir la resistencia antimicrobiana. Revisión bibliográfica: Una creciente resistencia antimicrobiana es un desafío global en salud pública que está asociada a un alto número de muertes anuales y quiere superar el cáncer como principal causa de mortalidad hasta 2050. Sin embargo, el desarrollo de nuevos antimicrobianos enfrenta obstáculos significativos, incluido el alto custo, incerteza de mercado e falta de interés de la industria farmacéutica. Buscando atenuar este escenario, nuevas alternativas antimicrobianas están sendo desenvolvidas y demostrando resultados promisores. La terapia fágica utiliza bacteriófagos para infectar bacterias, os peptídeos antimicrobianos, así como moléculas de aminoácidos con acción directa o inmunomoduladora, y los compuestos organometálicos con redes de coordinación de metais y ligantes orgánicos con propiedades antimicrobianas. Consideraciones finales: Cada una de las alternativas descritas no presentan ventajas y desafíos, pero todas ofrecen esperanza en el desarrollo de nuevos antimicrobianos eficaces. La resistencia antimicrobiana representa una amenaza de salud pública global y exige la búsqueda de soluciones innovadoras para garantizar el éxito continuo de la medicina moderna.
Referencias
ABDELHAMEED RM, et al. IRMOF‐3 Biological Activity Enhancement by Post‐Synthetic Modification. European Journal of Inorganic Chemistry, 2019; 2019(9): 1243-1249.
ALEXYUK P, et al. Isolation and characterization of lytic bacteriophages active against clinical strains of E. coli and development of a phage antimicrobial cocktail. Viruses, 2022; 14(11): 2381.
ANDRÉ V, et al. Mg-and Mn-MOFs boost the antibiotic activity of nalidixic acid. ACS Applied Bio Materials, 2019; 2(6): 2347-2354.
CHU HY, et al. Two silver-based coordination polymers constructed from organic carboxylate acids and 4,4'-bipyridine-like bidentate ligands: Synthesis, structure, and antimicrobial performances. Polyhedron, 2020; 188: 114684.
D’HERELLE F. An invisible microbe that is antagonistic to the dysentery bacillus. CR Acad Sci, 1917; 165: 373-375.
DASSANAYAKE RP, et al. Bovine NK-lysin-derived peptides have bactericidal effects against Mycobacterium avium subspecies paratuberculosis. Vet Res, 2021; 52(1): 1-8.
DENARDI LB, et al. Activity of MSI-78, h-Lf1-11 and cecropin B antimicrobial peptides alone and in combination with voriconazole and amphotericin B against clinical isolates of Fusarium solani. J Med Mycol, 2021; 31(2): 101119.
DENG X, et al. Conductive MOFs based on Thiol-functionalized Linkers: Challenges, Opportunities, and Recent Advances. Coord Chem Rev, 2022; 450: 214235.
DONG M, et al. BING, a novel antimicrobial peptide isolated from Japanese medaka plasma, targets bacterial envelope stress response by suppressing cpxR expression. Sci Rep, 2021; 11(1): 12219.
DUAN H, et al. Synergistic effect and antibiofilm activity of an antimicrobial peptide with traditional antibiotics against multi-drug resistant bacteria. Microb Pathog, 2021; 105056.
GHAFFAR I, et al. Synthesis of chitosan coated metal organic frameworks (MOFs) for increasing vancomycin bactericidal potentials against resistant S. aureus strain. Mater Sci Eng C, 2019; 105: 110111.
GOVINDARAJAN DK e KANDASWAMY K. Antimicrobial peptides: A small molecule for sustainable healthcare applications. Med Microecol, 2023; 18: 100090.
GUARDABASSI L, et al. One health: A multifaceted concept combining diverse approaches to prevent and control antimicrobial resistance. Clin Microbiol Infect, 2020; 26(12): 1604-1605.
GUPTA M, et al. Bacteriophages: An Alternative to Combat Antibiotic Resistance?. J Drugs Dermatology (JDD), 2022; 21(12): 1311-1315.
HANCOCK REW e LEHRER R. Cationic peptides: a new source of antibiotics. Trends Biotechnol, 1998; 16(2): 82-88.
KAKASIS A e PANITSA G. Bacteriophage therapy as an alternative treatment for human infections. A comprehensive review. Int J Antimicrob Agents, 2019; 53(1): 16-21.
IQVIA Institute. Global Use of Medicines 2023. Disponível em: https://iqvia.com/insights/the-iqvia-institute/reports/the-global-use-of-medicines-2023. Acessado em: 20 de setembro de 2023.
LI R, et al. Metal–Organic-Framework-Based Materials for Antimicrobial Applications. ACS Nano, 2021; 15(3): 3808-3848.
LIANG Y, et al. Role and modulation of the secondary structure of antimicrobial peptides to improve selectivity. Biomaterials Sci, 2020; 8(24): 6858-6866.
LIU Y, et al. The revitalization of antimicrobial peptides in the resistance era. Pharmacol Res, 2020; 105276.
MALIK S, et al. Bacteriophage cocktail and phage antibiotic synergism as promising alternatives to conventional antibiotics for the control of multi-drug-resistant uropathogenic Escherichia coli. Virus Res, 2021; 302: 198496.
MALLAKPOUR S, et al. Application of MOF materials as drug delivery systems for cancer therapy and dermal treatment. Coord Chem Rev, 2022; 451: 214262.
MELANDER RJ, et al. Overcoming intrinsic resistance in gram-negative bacteria using small molecule adjuvants. Bioorg Med Chem Lett, 2022; 129113.
MOHR KI. History of antibiotics research. In: How to Overcome the Antibiotic Crisis, 2016. p. 237-272.
NIMBALKAR MN e BHAT BR. Adsorção simultânea de azul de meteno e metais pesados de água usando Zr-MOF com grupo carboxílico livre. J Environ Chem Eng, 2021; 9(5): 106216.
OFIR G e SOREK R. Contemporary phage biology: from classic models to new insights. Cell, 2018; 172(6): 1260-1270.
QUARESMA S, et al. Novel antibacterial azelaic acid BioMOFs. Cryst Growth & Des, 2019; 20(1): 370-382.
RAJU P, et al. In vitro assessment of antimicrobial, antibiofilm and larvicidal activities of bioactive nickel metal organic framework. J Drug Deliv Sci Technol, 2020; 56: 101560.
TASHIRO S, et al. Simultaneous arrangement of up to three different molecules on the pore surface of a metal–macrocycle framework: cooperation and competition. Angew Chem Int Ed, 2014; 53(32): 8310-8315.
TROTTER AJ, et al. Tecnologias recentes e emergentes para o diagnóstico rápido de infecções e resistência antimicrobiana. Opinião Atual em Microbiologia, 2019; 51: 39-45.
TWORT FW. An investigation on the nature of ultra-microscopic viruses. Acta Kravsi, 1961.
VENTOLA CL. The antibiotic resistance crisis: part 1: causes and threats. Pharm Therapeutics, 2015; 40(4): 277.
WASEEM T, et al. New approaches to antimicrobial discovery: Current development and future prospects. In: New and Future Developments in Microbial Biotechnology and Bioengineering. Elsevier, 2020. p. 67-77.
WEN H, et al. Effective Treatment of A Broad-host-range Lytic Phage SapYZU15 in Eliminating Staphylococcus aureus From Subcutaneous Infection. Microbiol Res, 2023; 127484.
WORLD HEALTH ORGANIZATION et al. 2019 Antibacterial agents in clinical development: an analysis of the antibacterial clinical development pipeline, 2019.
YAGHI OM e LI H. Hydrothermal synthesis of a metal-organic framework containing large rectangular channels. J Am Chem Soc, 1995; 117(41): 10401-10402.
YAO L, et al. Development and challenges of antimicrobial peptide delivery strategies in bacterial therapy: A review. Int J Biol Macromol, 2023; 126819.
ZHAO X, et al. The application of MOFs-based materials for antibacterials adsorption. Coord Chem Rev, 2021; 440: 213970.
ZHANG X, et al. MOFs and MOF-Derived Materials for Antibacterial Application. J Funct Biomater, 2022; 13(4): 215.