Resumen
Objetivo: Reunir y analizar evidencias para comprender y correlacionar la influencia del síndrome de Takotsubo (TTS) inducido por la vacunación contra la Covid-19. Métodos: Revisión integrativa de literatura que incluyó artículos publicados entre 2021 y 2024, seleccionados a través de acceso a plataformas de publicación científica como Scielo, BVS, PubMed y Elsevier. Se utilizaron los descriptores Covid Vaccine y Takotsubo Syndrome. Se excluyeron los artículos que pertenecían a la tipología carta al editor, opinión de especialista, respuesta a la opinión, reseñas, capítulos de libro y relatos de casos aislados. Resultados: Se incluyeron 13 artículos, de los cuales 12 encontraron asociación entre la vacunación contra la Covid-19 y el TTS. Existe una mayor incidencia de esta complicación producida por la vacuna de ARN mensajero (ARNm) en comparación con las otras vacunas. Los síntomas más prevalentes en el TTS inducido por la vacunación incluyen dolor torácico, fiebre, tos, disnea, náuseas y síntomas digestivos. Se evidenciaron cambios electrocardiográficos (elevación del segmento ST e inversión de la onda T) y elevación de los marcadores cardíacos (troponina, CK-MB y NT-proBNP). Los exámenes de imagen mostraron opacidades en vidrio esmerilado, consolidación pulmonar y aumento de la silueta cardíaca. Consideraciones finales: Es fundamental monitorear los efectos de las vacunas contra la Covid-19 para desarrollar estrategias de prevención y manejo eficaces.
Referencias
AL HOURI HN, et al. Pathophysiology of stress cardiomyopathy: A comprehensive literature review. Annals of medicine and surgery, 2012; 82: 104671.
ALMAS T, el al. Epidemiology, clinical ramifications, and cellular pathogenesis of COVID-19 mRNA-vaccination-induced adverse cardiovascular outcomes: A state-of-the-heart review. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022; 149: 112843.
BARBIERI L, et al. Takotsubo syndrome in COVID-19 era: Is psychological distress the key? Journal of Psychosomatic Research, 2021; 140: 110297.
DE LIMA DHL, et al. Como elaborar uma revisão integrativa: sistematização do método científico. Revista Recien-Revista Científica de Enfermagem, 2022; 12(37): 334-345.
DE SOUZA DAB, et al. Relação dos efeitos colaterais com os tipos de vacinas da COVID-19. Research, Society and Development, 2023; 2(12): 10121243849.
FAZLOLLAHI A, et al. Cardiac complications following mRNA COVID‐19 vaccines: a systematic review of case reports and case series. Reviews in medical virology, 2022; 32(4): 2318.
GHASEMI H, et al. Takotsubo syndrome and COVID-19: A systematic review. Health science reports, 2022; 6(1): 972.
HANA D, et al. Clinical cardiovascular adverse events reported post-COVID-19 vaccination: are they a real risk? Current Problems in Cardiology, 2022; 47(3): 101077.
HEGDE S, et al. Characteristics and outcome of patients with COVID-19 complicated by Takotsubo cardiomyopathy: case series with literature review. Open heart, 2020; 7(2): 001360.
HO JS, et al. A review of COVID-19 vaccination and the reported cardiac manifestations. Singapore medical journal, 2023; 64(9): 543-549.
KHALID AS, et al. Global reports of takotsubo (stress) cardiomyopathy following COVID-19 vaccination: A systematic review and meta-analysis. International journal of cardiology. Heart & vasculature, 2022; 43: 101108.
LI C, et al. Takotsubo syndrome and vaccines: a systematic review. ESC Heart Failure, 2024.
LI P, et al. Vaccination-induced takotsubo syndrome: a systematic review. Journal of the American College of Cardiology, 2023; 81(8-Supplement): 575-575.
LI YE, et al. Clinical cardiovascular emergencies and the cellular basis of COVID-19 vaccination: from dream to reality? International journal of infectious diseases: IJID: official publication of the International Society for Infectious Diseases, 2022; 124: 1–10.
MOADY G e ATAR S. Takotsubo Syndrome During the COVID-19 Pandemic: State-of-the-Art Review. CJC open, 2021; 3(10): 1249–1256.
OKURA H. Update of takotsubo syndrome in the era of COVID-19. Journal of cardiology, 2021; 77(4): 361–369.
PAKNAHAD MH, et al. Cardiovascular complications of COVID-19 vaccines: A review of case-report and case-series studies. Heart & lung: the journal of critical care, 2023; 59: 173–180.
POGRAN E, et al. Takotsubo syndrome before and during the COVID-19 pandemic in Austria: a retrospective cohort study (TOSCA-19). ESC heart failure, 2023; 10(6): 3667–3676.
ROSH B, et al. Trends in occurrence of takotsubo syndrome and association with SARS-CoV-2 infection and COVID-19 vaccination. Journal of Cardiovascular Medicine, 2023; 24(11): 815-821.
SHAH RM, et al. Takotsubo Syndrome and COVID-19: Associations and Implications. Current problems in cardiology, 2021; 46(3): 100763.
SINGH B, et al. A Systematic Review of COVID-19 Vaccine-Induced Takotsubo Cardiomyopathy: A 2023 Update. Cureus, 2023; 15(12): 50319.
TEDESCHI A, et al. Recent highlights on acute myocardial infarction and takotsubo syndrome from the International Journal of Cardiology: Heart & Vasculature. International Journal of Cardiology. Heart & Vasculature, 2022; 43.
WONG MK, et al. COVID-19 Mortality and Progress Toward Vaccinating Older Adults - World Health Organization, Worldwide, 2020-2022. MMWR. Morbidity and mortality weekly report, 2023; 72(5): 113–118.
