Palabras clave
Síndrome post COVID-19
Manifestaciones neurológicas
Secuelas neurológicas
Cómo citar
Copyright © | Todos los derechos reservados.
La revista posee los derechos de autor exclusivos para la publicación de este artículo en los términos de la ley brasileña 9610/98.
Reproducción parcial
El uso de partes de los textos, figuras y cuestionario del artículo es libre, siendo obligatoria la citación de los autores y revista.
Reproducción total
Está expresamente prohibido y debe ser autorizado por la revista.
Resumen
Objetivo: Revisar los principales estudios en la literatura médica que describen manifestaciones neurológicas relacionadas con el COVID-19. La investigación será una revisión bibliográfica de literatura de tipo narrativo. Revisión bibliográfica: Evidencia cada vez más sólida demuestra el carácter multisistémico del COVID-19, causado por el SARS-CoV-2, destacando los más diversos trastornos neurológicos que se manifiestan en forma de síndromes (demencia, parkinsoniano, epiléptico, motor, amnésico, conductual, entre otros). Además, los estudios destacan las manifestaciones neurológicas con mayor prevalencia, como dolores de cabeza, vértigo, crisis epilépticas, alteración de la conciencia, ataxias y enfermedad cerebrovascular aguda, así como enfermedades relacionadas con el sistema nervioso periférico (SNP) como trastornos sensoriales, déficits del gusto, olfato, visión y además del dolor. Consideraciones finales: Considerando las complicaciones neurológicas asociadas al COVID-19, es fundamental reconocer que el virus SARS-CoV-2 no solo afecta el sistema respiratorio, sino que también puede tener impactos significativos en el sistema nervioso central y periférico. Estudios e informes clínicos han documentado una variedad de manifestaciones neurológicas en pacientes con COVID-19, desde síntomas leves, como dolor de cabeza y mareos, hasta complicaciones más graves, como encefalopatía, accidente cerebrovascular, encefalitis y síndrome de Guillain-Barré.
Referencias
AGHAJANIAN S, et al. The effect of COVID-19 on Multiple Sclerosis relapse: A systematic review and meta-analysis. Mult Scler Relat Disord. 2024; 81: 105-128.
ALLAHYARI F, et al. Covid-19 vaccines and neurological complications: a systematic review. Z Naturforsch C J Biosci, 2022; 78(1-2): 1-8.
AZZAM A, et al. The burden of persistent symptoms after COVID-19 (long COVID): a meta-analysis of controlled studies in children and adults. Virol J. 2024; 21(1): 16.
BRAGATTO MG, et al. Estudo das sequelas neuroanatômicas associadas à Síndrome Pós-COVID-19. Revista Eletrônica Acervo Saúde. REAS Vol. 2021; 13(12).
CENSI S, et al. Guillain-Barré syndrome and COVID-19 vaccination: a systematic review and meta-analysis. J Neurol, 2024; 271(3): 1063-1071.
CHEN WP, et al. Investigation of Neurological Complications after COVID-19 Vaccination: Report of the Clinical Scenarios and Review of the Literature. Critical Reviews in Microbiology, 2023.
COVID-19 Vaccines (Pfizer-BioNTech and Moderna): Update from the Advisory Committee on Immunization Practices. Centers for Disease Control and Prevention, [S. l.], 2021. Disponível em: https ://www.cdc.gov/mmwr/volumes/70/wr/mm7032e4.htm#suggestedcitation. Acessado em: 11 de abril de 2024.
DESILLES JP, et al. Impact of COVID-19 on thrombus composition and response to thrombolysis: Insights from a monocentric cohort population of COVID-19 patients with acute ischemic stroke. J Thromb Haemost. 2022; 20(4): 919-928.
ELLUL MA, et al. Neurological associations of COVID-19. Lancet Neurol. 2020; 19(9): 767-783.
GOMES AS, et al. Associação entre o COVID-19 e manifestações neurológicas. Braz. J. of Develop. 2020; 6(11): 88950-88961.
GOMES LP, et al. Neurological and neuropsychiatric manifestations of post-COVID-19 condition in South America: a systematic review of the literature. Arq Neuropsiquiatr. 2024; 82(1): 1-8.
GONZÁLEZ-HERAZO MA, et al. Post-COVID 19 Neurological Syndrome: a fresh challenge in neurological management. Journal of Neurology and Neurosurgery. 2021; 55(4).
IGNÁCIO FG, et al. Prevalence and Associated Factors of SARS caused by Covid-19 in Adults and Aged People with Chronic Cardiovascular Disease: A Critical Analysis. Cardiol. 2020; 114(5): 805-16.
JARRAHI A, et al. Neurological consequences of COVID-19: what have we learned and where do we go from here? Journal of Neuroinflammation. PubMed. 2020.
KANDUC D, et al. Sobre os determinantes moleculares do ataque SARS- CoV-2. Journal of Clinical Immunology. 2020.
LUO W, et al. Ischemic stroke associated with COVID-19: a systematic review and meta-analysis. J Neurol. 2022; 269(4): 1731-1740.
MANZANO GS, et al. Acute Disseminated Encephalomyelitis and Acute Hemorrhagic Leukoencephalitis Following COVID-19: Systematic Review and Meta-synthesis. Neurol Neuroimmunol Neuroinflamm. 2021; 8(6): 1080.
NEHME MD, et al. Symptoms after COVID-19 vaccination in patients with PASC. Journal of General Internal Medicine, 2022.
NING F, et al. Safety of SARS-CoV-2 vaccine in patients with autoimmune neurological conditions: A systematic review and meta-analysis. Heliyon. 2023; 10(1): 23944.
ØSTERGAARD SD, et al. Thromboembolism and the Oxford– AstraZeneca COVID-19 vaccine: side-effect or coincidence? National Library of Medicine. 2021.
PATONE M, et al. Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection. Nature Medicine. 2021; 2146(27): 2144–2153.
PIMENTEL V, et al. Guillain-Barré syndrome associated with COVID-19: A systematic review. Brain Behav Immun Health. 2023; 28: 100578.
PITLIYA AD, et al. A Systematic Review Unraveling the Intricate Neurological Spectrum of COVID-19: Manifestations, Complications, and Transformative Insights for Patient Care. Neurol India. 2024; 72(1): 11-19.
PLATTO SX, et al. COVID19: an announced pandemic. Cell Death & Disease. 2020; 11(9): 799.
PREMRAJ L, et al. Mid and long-term neurological and neuropsychiatric manifestations of post-COVID-19 syndrome: A meta-analysis. J Neurol Sci. 2022; 434: 120-162.
ROCHMAWATI E, et al. Persistent symptoms among post-COVID-19 survivors: A systematic review and meta-analysis. J Clin Nurs. 2024; 33(1): 29-39.
ROSENBLUM HG, et al. Use of COVID-19 Vaccines After Reports of Adverse Events Among Adult Recipients of Janssen (Johnson & Johnson) and mRNA COVID-19 Vaccines (Pfizer-BioNTech and Moderna): Update from the Advisory Committee on Immunization Practices. Centers for Disease Control and Prevention. 2021.
RUS MA, et al. Acute Myocardial Infarction during the COVID-19 Pandemic: Long-Term Outcomes and Prognosis-A Systematic Review. Life (Basel). 2024; 14(2): 202.
SCHULTZ NH, et al. Thrombosis and Thrombocytopenia after ChAdOx1 nCoV- 19 Vaccination. The New England Journal of Medicine. 2021.
SHEN Y, et al. Association of seizures with COVID-19 infection in underage during the pandemic: A systematic review and meta-analysis. Epilepsy Res. 2023; 197: 107223.
SHI Y, et al. COVID-19 infection: the perspectives on immune responses. Version 2 Cell Death Differ. 2020; 27: 1451-1454.
STOIAN A, et al. The Occurrence of Acute Disseminated Encephalomyelitis in SARS-CoV-2 Infection/Vaccination: Our Experience and a Systematic Review of the Literature. Vaccines (Basel). 2023; 11(7): 1225.
VALENTE F, et al. Vacinação obrigatória é constitucional. ConJur. 2020; 12(9): 1529.
WHO. WORLD HEALTH ORGANIZATION. Coronavirus disease (COVID-19) outbreak. Geneva: World Health Organization, 2020.
YAO M, et al. Disentangling the common genetic architecture and causality of rheumatoid arthritis and systemic lupus erythematosus with COVID-19 outcomes: Genome-wide cross trait analysis and bidirectional Mendelian randomization study. J Med Virol. 2023; 95(2): 28570.
ZHANG JJ, et al. Risk and Protective Factors for COVID-19 Morbidity, Severity, and Mortality. Clin Rev Allergy Immunol. 2023; 64(1): 90-107.