Resumen
Objetivo: Evaluar los niveles séricos de vitamina B12 en mujeres embarazadas y la importancia del cribado prenatal. Métodos: Este fue un estudio piloto longitudinal, con 79 gestantes. Resultados: La edad media de las pacientes fue 31,4 + 7,4 años, con un promedio de 2,3 embarazos + 1,3; 0,9 + 1,0 partos y 0,3 + 0,7 abortos. La dosis de vitamina B12 fue de 374 ± 190 pg/ml, considerándose normal en el 75% de las gestantes estudiadas, límite en el 16,7%, baja en el 6,9% y alta en el 1,4%. En el segundo trimestre, el promedio de B12 fue de 321 ± 191 pg/ml, con 20,8% en dosis baja, 39,6% normal y 37,5% en el límite. En el tercer trimestre, la media de B12 fue de 302 ± 222 pg/ml, siendo 28,2% dosis baja, 28,2% normal, 38,5% límite y 5,1% alta. No hubo asociación entre las dosis de vitamina B12 y el consumo de carne, leche y huevos (p>0,05). No hubo casos de confusión, demencia, pérdida de sensibilidad u hormigueo en las extremidades, pero sí asociación con diabetes mellitus gestacional (DMG). Conclusion: Considerando la caída de la vitamina B12 durante la atención prenatal y el gran número de dosis dudosas, se debe considerar el cribado prenatal.
Referencias
ACHEBE MM e GAFTER-GVILI A. How I treat anemia in pregnancy: iron, cobalamin, and folate. Blood. 2017; 129 (8): 940-9.
BONDEVIK G, et al. Homocysteine and methylmalonic acid levels in pregnant Nepali women. Should cobalamin supplementation be considered? European Journal of Clinical Nutrition, 2001; 55 (10): 856-64
BONILLA C. et al. Vitamin B-12 Status during Pregnancy and Child’s IQ at Age 8: A Mendelian Randomization Study in the Avon Longitudinal Study of Parents and Children. PLoS ONE, 2012; 7(12): e51084.
CAVALCANTI RA. Concentrações séricas de vitamina B12, folato intra-eritrocitário e hemoglobina em mulheres em idade fértil e sua associação com variáveis socioeconômicas, demográficas, antropométricas e do estilo de vida. Universidade Federal de Pernambuco (Tese). Disponível on-line. Acessado em abril de 2024. < https://repositorio.ufpe.br/bitstream/123456789/31868/4/TESE%20Rafaella%20de%20Andrade%20Silva%20Cavalcanti.pdf.txt>
CHEN X, et al. Association of Maternal Folate and Vitamin B12 in Early Pregnancy with Gestational Diabetes Mellitus: A Prospective Cohort Study. Diabetes Care. 2021; 44(1): 217-223
DE BENOIST, B. Conclusions of a WHO Technical Consultation on Folate and Vitamin B 12 Deficiencies. Food and Nutrition Bulletin, 2008; 29 (2): 238-44.
EL BEITUNE P, et al. Nutrição durante a gravidez. Femina, 2020; 48 (4): 245-56.
FINKELSTEIN JL, et al. Suplementação de vitamina B 12 para mulheres durante a gestação. Cochrane. Disponível on line < https://www.cochrane.org/pt/CD013823/PREG_suplementacao-de-vitamina-b-12-para-mulheres-durante-gestacao>.
KRISHNAVENI GV, et al. Low plasma vitamin B12 in pregnancy is associated with gestational 'diabesity' and later diabetes. Diabetologia. 2009;52 (11): 2350-8.
MAHER A e MALEFORA AS. The Relationship Between Folate, Vitamin B12 and Gestational Diabetes Mellitus with Proposed Mechanisms and Fetal Implications. J Family Reprod Health. 2021; 15(3): 141-149.
MARTINEZ GLM et al. Impactos da vitamina B12 para a mãe e sua prole: revisão de literatura. 2023. Disponível on line < https://repositorio.pucgoias.edu.br/jspui/bitstream/123456789/5722/1/ARTIGO%20B12%20REAS%20%281%29.pdf>. Acessado em abril de 2024.
MAYENGBAM S, et al. Metabolic consequences of discretionary fortified beverage consumption containing excessive vitamin B levels in adolescents. PLoS One. 2019; 14(1): e0209913.
MEANS RT, et al. Treatment of vitamin D and folate deficiencies. UptoDate. Disponível on line< https://medilib.ir/uptodate/show/7154>. Acessado em abril de 2024.
PANIZ C, et al. Fisiopatologia da deficiência de vitamina B12 e seu diagnóstico laboratorial. Jorn. Bras. Patol Med Lab., 2005; 41(5): 323-34.
RAMAKRISHNAN U, et al. Effect of Women’s Nutrition before and during Early Pregnancy on Maternal and Infant Outcomes: A Systematic Review. Paediatric and Perinatal Epidemiology, 2012; 26 (1): 285–301.
RASHID S, et al. Review of Vitamin B12 deficiency in pregnancy: a diagnosis not to miss as veganism and vegetarianism become more prevalent. European Journal of Haematology, 2021; 106(4): 450-5.
ROGNE T, et al. Associations of Maternal Vitamin B12 Concentration in Pregnancy with the Risks of Preterm Birth and Low Birth Weight: A Systematic Review and Meta-Analysis of Individual Participant Data. Am J Epidemiol. 2017; 185 (3): 212-23.
RUBER TA, et al. Vitaminas do complexo B: uma breve revisão. Revista Jovens Pesquisadores, 2017; 7 (1): 30-45.
SEBASTIANI G, et al. The Effects of Vegetarian and Vegan Diet during Pregnancy on the Health of Mothers and Offspring. Nutrients, 2019; 6(11): 557.
SERAPINAS D, et al. The importance of folate, vitamins B6 and B12 for the lowering of homocysteine concentrations for patients with recurrent pregnancy loss and MTHFR mutations. Reprod Toxicol., 2017; 72 (9): 159-63.
SUKUMAR N, et al. Vitamin B12 Status among Pregnant Women in the UK and Its Association with Obesity and Gestational Diabetes. Nutrients, 2016; 8(12): 768.
VEENA SR, et al. Higher Maternal Plasma Folate but Not Vitamin B-12 Concentrations during Pregnancy Are Associated with Better Cognitive Function Scores in 9- to 10- Year-Old Children in South India. The Journal of Nutrition, 2010; 140 (5): 1014-22.
ZIMMERMMANN JB, et al. Dosagem sérica da vitamina D em mulheres durante o controle ginecológico. Rev Fac Ciênc Méd Sorocaba. 2020; 22(2): 77-82.
ZIMMERMMANN JB, et al. Gestação de Alto Risco: Do pré-natal ao puerpério. 2021; 888p.
BHATE VK, et al. Vitamin B12 and folate during pregnancy and offspring motor, mental and social development at 2 years of age. Journal of Developmental Origins of Health and Disease. 2012; 3:123–30.
