Palabras clave
Mielinización
Neuroinflamación
Microglia
Activación inmune materna
Cómo citar
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Resumen
Objetivo: Examinar los diferentes mecanismos relacionados con la neuroinflamación que están asociados con la promoción del TEA. Métodos: Se trata de una revisión integradora de la literatura, con artículos publicados entre 2019 y 2024, en portugués e inglés, con texto completo. Se utilizó la pregunta orientadora: ¿Cómo influyen los mecanismos neuroinflamatorios en la manifestación del TEA? El trabajo se realizó entre enero y abril de 2024, realizando un levantamiento bibliográfico en las bases de datos: PubMed National Institutes of Health, National Center for Biotechnology Information (NCBI), MDPI, a través de Science and Health Descriptors (DECs): Neuroinflamación, Mielinización, Microglia, Notch, Célula glial, Microbiota, Activación Inmunitaria Materna relacionada con el Autismo. Resultados: Luego del análisis y aplicación de los criterios de inclusión y exclusión, se localizaron 2562 trabajos, siendo eliminados 2539 trabajos por no ajustarse a la temática propuesta o no ajustarse a los criterios de exclusión, resultando como muestra final 25 artículos. Consideraciones finales: Es importante estudiar el proceso neuroinflamatorio para desarrollar enfoques terapéuticos, como el uso de antiinflamatorios, antioxidantes, inhibidores de la vía de Notch para mejorar la calidad de vida de las personas con TEA.
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