Palabras clave
Perfil inmunohematológico
Marcadores informativos de ascendencia
Población mixta
Cómo citar
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Resumen
Objetivo: Evaluar los perfiles hematológicos y linfocitarios de individuos con COVID-19, así como identificar el perfil ancestral a través de Marcadores Informativos de Ascendencia de dos ciudades de la región Nordeste de Brasil. Métodos: Se analizaron datos de 58 personas con COVID-19 que presentaban condiciones clínicas leves (39) y graves (19). El perfil de linfocitos se identificó mediante inmunofenotipado y genotipado mediante análisis de PCR y qPCR. Los datos fueron analizados mediante estadística descriptiva utilizando el software IBM SPSS Statistics. El estudio fue aprobado por el Comité de Ética en Investigación (ICS-UFBA). Resultados: Los individuos del grupo grave mostraron un aumento de leucocitos y neutrófilos totales, una disminución de eritrocitos, hemoglobina, hematocrito y linfocitos en comparación con los individuos del grupo leve. Asimismo, el grupo severo mostró una disminución en los perfiles celulares de células TCD4+, TCD8+ y linfocitos B. En relación al perfil ancestral, ambos grupos presentaron un mayor perfil genómico ancestral europeo. Sin embargo, el grupo grave tenía un mayor porcentaje de ascendencia africana en comparación con el grupo leve. Conclusión: La ascendencia no se asoció con la gravedad, pero los resultados se corresponden con los hallazgos de que las respuestas inmunitarias de los individuos desempeñan un papel crucial en la COVID-19.
Referencias
ABE-SANDES K, et al. Ancestralidade Genômica, nível socioeconômico e vulnerabilidade ao HIV/aids na Bahia, Brasil. Saúde e Sociedade. 2010; 19: 75–84.
AL-ABDI S e AL-AAMRI M. G6PD deficiency in the COVID-19 pandemic: Ghost within Ghost. Hematology/Oncology and Stem Cell Therapy. 2020; 14(1): 84-85.
AZKUR AK, et al. Immune response to SARS‐CoV‐2 and mechanisms of immunopathological changes in COVID‐19. Allergy. 2020; 75 (7): 1564–81.
BORGES GM e CRESPO CD. Aspectos demográficos e socioeconômicos dos adultos brasileiros e a COVID-19: uma análise dos grupos de risco a partir da Pesquisa Nacional de Saúde, 2013. Cadernos de SaúdePública. 2020; 36(10): 141020.
CAVALCANTE LN, et al. Genetic ancestry analysis in non-alcoholic fatty liver disease patients from Brazil and Portugal. World Journal of Hepatology. 2015; 7(10): 1433-1438.
CODD AS, et al. Neutrophilia, lymphopenia and myeloid dysfunction: a living review of the quantitative changes to innate and adaptive immune cells which define COVID-19 pathology. Oxford Open Immunology. 2021; 2(1): 16.
COZIER YC, et al. Lower serum 25(OH)D levels associated with higher risk of COVID-19 infection in U.S. Black women. PLOS ONE. 2021; 16(7): 255132.
DU RH, et al. Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study. European Respiratory Journal. 2020; 55(5): 2000524.
FARSHBAFNADI M, et al. Aging & COVID-19 susceptibility, disease severity, and clinical outcomes: The role of entangled risk factors. Experimental Gerontology. 2021; 154(15): 111507.
FERDINAND K, et al. Contemporary and Future Concepts on Hypertension in African Americans: COVID-19 and Beyond. Journal of the National Medical Association. 2020; 112(3): 315–23.
FERREIRA RBS e CAMARGO CL. Vulnerabilidade da população negra brasileira frente à evolução da pandemia por COVID-19. RevistaCuidarte. 2021; 12(2): 1-12.
FU J, et al. The clinical implication of dynamic neutrophil to lymphocyte ratio and D-dimer in COVID-19: A retrospective study in Suzhou China. Thrombosis Research. 2020; 192: 3–8.
GHOBADI H, et al. Role of leukocytes and systemic inflammation indexes (NLR, PLR, MLP, dNLR, NLPR, AISI, SIR-I, and SII) on admission predicts in-hospital mortality in non-elderly and elderly COVID-19 patients. Frontiers in Medicine. 2022; 9: 916453.
HU B, et al. Characteristics of SARS-CoV-2 and COVID-19. Nature Reviews Microbiology. 2020; 20(5): 315.
IBGE. Censo 2010. Govbr 2010. https ://cidades.ibge.gov.br/brasil/ba/salvador/pesquisa/23/25359. Acess: April 2024.
JAIN SK, et al. The potential link between inherited G6PD deficiency, oxidative stress, and vitamin D deficiency and the racial inequities in mortality associated with COVID-19. Free Radical Biology and Medicine. 2020; 161: 84–91.
JESENAK M, et al. Immune Parameters and COVID-19 Infection – Associations With Clinical Severity and Disease Prognosis. Frontiers in Cellular and Infection Microbiology. 2020; 10: 364.
JING Y, et al. SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism. Signal Transduction and Targeted Therapy. 2021; 6(1): 345.
KARIMI SHAHRI M, et al. COVID‐19 and hematology findings based on the current evidences: A puzzle with many missing pieces. International Journal of Laboratory Hematology. 2020; 43(2): 160–8.
MACKEY K, et al. Racial and Ethnic Disparities in COVID-19–Related Infections, Hospitalizations, and Deaths. Annals of Internal Medicine. 2021; 174 (3): 362-373.
MERAD M, et al. The immunology and immunopathology of COVID-19. Science. 2022; 375(6585): 1122–7.
MOSS P. The T cell immune response against SARS-CoV-2. Nature Immunology. 2022; 23(2): 186–93.
MS. MINISTÉRIO DA SAÚDE. Coronavírus Brasil. Covidsaudegovbr 2024. https ://covid.saude.gov.br/ Acess: July, 2024.
NORIN AJ, et al. HLA B53 is associated with a poor outcome in black COVID-19 patients. HumanImmunology. 2021; 82(10): 713-718.
PENA J. Razões para banir o conceito de raça da medicina brasileira. HistoriaCienciasSaude-manguinhos. 2005; 12(2): 321–46.
PENA SDJ, et al. Genetic admixture in Brazil. American Journal of Medical Genetics Part C: Seminars in Medical Genetics. 2020; 184(4): 928-938.
PRICE-HAYWOOD EG, et al. Hospitalization and Mortality among Black Patients and White Patients with Covid-19. New England Journal of Medicine. 2020; 382(26): 2534-2543.
QUEIROZ EM, et al. Genetic composition of a Brazilian population: the footprint of the Gold Cycle. Geneticsand molecular research: GMR. 2013; 12(4): 5124-5133.
SANTOS MPAD, et al. População negra e Covid-19: reflexões sobre racismo e saúde. EstudosAvançados. 2020; 34(99): 225–44.
SHELTON JF, et al. Trans-ancestry analysis reveals genetic and nongenetic associations with COVID-19 susceptibility and severity. Nature Genetics. 2021; 53(6): 801-808.
SHRIVER MD, et al. Ethnic-affiliation estimation by use of population-specific DNA markers. American Journal of Human Genetics. 1997; 60(4): 957–64.
SONG JW, et al. Immunological and inflammatory profiles in mild and severe cases of COVID-19. Nature Communications. 2020; 11(1): 3410.
SUN S, et al. Abnormalities of peripheral blood system in patients with COVID-19 in Wenzhou, China. ClinicaChimicaActa; International Journal of Clinical Chemistry. 2020; 507: 174-180.
TAO Z, et al. Anemia is associated with severe illness in COVID‐19: A retrospective cohort study. Journal of Medical Virology. 2020; 93(3): 1478–88.
TERPOS E, et al. Hematological findings and complications of COVID ‐19. American Journal of Hematology. 2020; 95(7): 834-847.
WANG J, et al. Excessive Neutrophils and Neutrophil Extracellular Traps in COVID-19. Frontiers in Immunology. 2020; 11: 2063.
WANG L, et al. Coronavirus disease 2019 in elderly patients: Characteristics and prognostic factors based on 4-week follow-up. Journal of Infection. 2020; 80(6): 639-645.
WESTMEIER J, et al. Impaired Cytotoxic CD8+ T Cell Response in Elderly COVID-19 Patient. mBio. 2020; 11(6): 2805-20.
WOOL GD e MILLER JL. The impact of COVID-19 disease on platelets and coagulation. Pathobiology. 2020; 88(1): 1–13.
ZHOU F, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. The Lancet. 2020; 395(10229): 1054-1062.