Palabras clave
Recubrimiento de la pulpa dental
Endodoncia
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Resumen
Objetivo: Dado el uso generalizado de losbisfosfonatos (BF) para eltratamiento de condiciones como laosteoporosis y lasmetástasisóseas, y lanecesidad de prevenir laosteonecrosis de los maxilares inducida por bisfosfonatos (ONM), es esencialcomprendersu impacto enla terapia pulpar vital (TPV). Métodos: Este estudioevaluólarespuesta pulpar y periapical, así como lacapacidad de reparacióndelrecubrimiento pulpar directo (RPD) enun modelo animal pretratadoconbisfosfonatos. Utilizando 36 molares inferiores de 18 ratas Wistar, losanimalesfueron divididos segúnel material restaurador (MTA o Cotosol) y eltratamiento farmacológico (Ácido Zoledrónico o solución salina). Resultados: El grupo ZA + MTA mostrólosmejores resultados, conun 44,5% de inflamación leve (p=0,033), un 88,9% de ausencia de patología periapical (p=0,034) y un 55,6% de formación leve de puentedentinario (p=0,01). Además, el 33,3% del grupo mantuvo una morfologíatisular normal (p=0,024), conla menor ocurrencia de calcificación distrófica (37,5%) (p=0,032). Conclusión: Los hallazgossugieren que el MTA reduceel infiltrado inflamatorio, promuevelaformación de dentina y favorecelasalud periapical, incluso en presencia de bisfosfonatos. Estos resultados destacanel potencial del MTA para mitigar losefectos adversos de losbisfosfonatosenlacicatrización pulpar y periapical.
Referencias
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