Palabras clave
Estrés oxidativo
Nanoemulsión
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Resumen
Objetivo: Evaluar los efectos terapéuticos de la nanoemulsión de aceite de Cannabis sativa (CBDON) sobre las alteraciones renales inducidas por el ácido valproico (VPA) en ratas. Métodos: Ratas Wistar hembras preñadas fueron expuestas a VPA y sus crías recibieron tratamiento con nanoemulsión de CBD en concentraciones de 1% y 2%. Después de 60 días, se realizaron evaluaciones mediante biometría corporal, morfometría renal y análisis de estrés oxidativo, con cuantificación de la actividad de malondialdehído (MDA) y enzima antioxidante. Los datos fueron analizados mediante estadística descriptiva e inferencial. Resultados: El VPA provocó una reducción del peso corporal y cambios en las estructuras renales, como una disminución del área y el diámetro glomerular. El tratamiento con nanoemulsión de CBD, especialmente a una concentración del 2%, mostró un efecto positivo en la recuperación de los parámetros morfométricos renales y la reducción del estrés oxidativo, revirtiendo parcialmente el daño causado por el VPA. Se observó un aumento de la actividad de las enzimas antioxidantes y una disminución de MDA en los grupos tratados con CBD. Conclusión: El estudio sugiere que la nanoemulsión de CBD puede tener un efecto nefroprotector, mitigando los cambios renales inducidos por VPA durante el período intrauterino.
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