Palabras clave
Antioxidantes
Compuestos naturales
Histopatología
Terapia multidrogas
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Resumen
Objetivo: Evaluar la acción antitumoral del Propóleo Verde y la Melatonina. Métodos: Se implantaron células de carcinoma de Ehrlich en tejido subcutáneo de ratones machos Swiss Webster, los cuales se dividieron en grupos experimentales: Control, Animales que recibieron 2 mg/kg de Melatonina; Animales tratados con 50 mg/Kg de Propóleo Verde; Animales tratados con 5 mg/Kg de Paclitaxel; Animales tratados con Melatonina y Propóleo Verde; Animales tratados con Melatonina y Paclitaxel; Animales tratados con Propóleo Verde y Paclitaxel; y Animales tratados con Melatonina, Propóleo Verde y Paclitaxel. Resultados: Todos los protocolos que contenían Propóleo Verde previnieron lesiones metastásicas y degenerativas en pulmón e hígado, minimizando los efectos secundarios de la polifarmacia. Aunque bajo las condiciones aplicadas en este estudio, la Melatonina no fue eficiente en la inhibición de EST, atenuó la miocarditis, la necrosis tubular renal y la metástasis pulmonar. Conclusión: El tratamiento con Melatonina, Propóleo Verde y Paclitaxel mostró los mejores resultados en la reducción del peso tumoral, índice mitótico e inhibición tumoral, reforzando la efectividad de la asociación de compuestos naturales con quimioterapia en la reducción de cambios histopatológicos tisulares.
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