Palabras clave
Enzima conversora de angiotensina
Mutação INDEL
Metanálise
Cómo citar
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Resumen
Objetivo: Realizamos uma revisão sistemática e meta-análise para avaliar a associação entre polimorfismos nos genes ECA e ECA2 e o desenvolvimento de ND. Métodos: Buscamos registros em seis bases de dados (NCBI/PubMed, MEDLINE, Biblioteca Cochrane, Biblioteca Virtual em Saúde, Scielo e Embase) e na literatura cinzenta (Google Scholar e citações). Dois revisores independentes selecionaram os artigos de acordo com os critérios de inclusão e exclusão definidos. Resultados: A busca sistemática da literatura identificou 114 registros nas bases de dados. Ao final da seleção, 5 estudos foram incluídos na análise qualitativa e 4 estudos foram incluídos na análise quantitativa. Todos os estudos incluídos foram estudos de caso-controle e realizados nas populações iraquiana, paquistanesa e turca. Conclusão: De acordo com a metanálise, os genótipos ID+DD do polimorfismo I/D do gene da ECA estão associados a um risco aumentado de desenvolvimento de ND (OR=1,43, IC=1,01-2,03, p=0,0464). Nossa análise sugere ainda que o alelo D também é um marcador de risco para ND (OR = 1,42, IC = 1,19–1,68, p < 0,0001), e resultados semelhantes foram encontrados anteriormente. Mais estudos observacionais em diferentes populações são necessários para confirmar esta associação.
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