Palabras clave
Selênio
Suplementos Dieteticos
Genómica
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Resumen
Objetivo: Nos propusimos dilucidar, a través de una revisión sistemática y un metaanálisis, cómo la exposición al selenio puede influir en la activación de la vía de señalización PI3K/Akt/GLUT-4 en modelos animales de diabetes. Métodos: Se realizó una búsqueda en las bases de datos PubMed/Medline, Cochrane Library, LILACS, Web of Science y Scopus, sin límite de tiempo, con foco en estudios realizados en modelos animales de diabetes. Resultados: Se incluyeron 13 artículos en esta revisión. Los hallazgos muestran que la suplementación con selenio resultó en una mayor expresión de la proteína GLUT-4, así como una mejoría de la glucosa en ayunas, la insulina en ayunas y el HOMA-IR en el modelo animal, ignorando estudios realizados en humanos que muestran un efecto diabetogénico de este mineral en muchos estudios realizados. De igual manera, este metaanálisis muestra resultados controvertidos con respecto a la modulación de la vía PI3K/Akt/GLUT-4 y el metabolismo de la glucosa en diferentes modelos animales. Consideraciones finales: La relación entre el selenio y la señalización de insulina es compleja y depende de la dosis, el compuesto y el tejido, es importante interpretar estos resultados con cuidado.
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