Palabras clave
Cannabidiol
Riñón
Hígado
Cómo citar
Copyright © | Todos los derechos reservados.
La revista posee los derechos de autor exclusivos para la publicación de este artículo en los términos de la ley brasileña 9610/98.
Reproducción parcial
El uso de partes de los textos, figuras y cuestionario del artículo es libre, siendo obligatoria la citación de los autores y revista.
Reproducción total
Está expresamente prohibido y debe ser autorizado por la revista.
Resumen
Objetivo: Evaluar los efectos de la nanoemulsión de cannabidiol (CBD) en ratas sometidas a desnutrición proteica gestacional sobre la reversión de alteraciones hepáticas y renales en la descendencia. Revisión bibliográfica: La evidencia científica indica que la deficiencia proteica materna está asociada con un aumento del estrés oxidativo, la inflamación y disfunciones celulares, lo que puede resultar en daños morfofuncionales irreversibles, dependiendo del período gestacional en el que ocurra la restricción nutricional. En este contexto, la nanoemulsión de cannabidiol (CBD) surge como una estrategia terapéutica prometedora, debido a sus propiedades antioxidantes, antiinflamatorias y moduladoras del sistema endocannabinoide. Consideraciones finales: Los hallazgos demuestran que la nanoemulsión de CBD mejora la biodisponibilidad del compuesto, reduce la producción de especies reactivas de oxígeno y atenúa las respuestas inflamatorias, contribuyendo a la preservación estructural y funcional de los órganos hepáticos y renales. A pesar de los resultados prometedores, se requieren estudios adicionales para la estandarización de las dosis y la evaluación de la seguridad materno-fetal.
Referencias
ALAMEDDINE M, et al. Effect of lactational low-protein diet on skeletal muscle during adulthood and ageing in male and female mouse offspring. Nutrients, 2024; 16(17): 2926.
AQUINO A, et al. Nanoemulsions of cannabidiol, Δ9-tetrahydrocannabinol, and their combination similarly exerted anticonvulsant and antioxidant effects in mice treated with pentylenetetrazole. Pharmaceuticals, 2025; 18(6): 782.
ARINHO AM, SILVA NR. Anti-inflammatory effects of cannabinoids. BrJP, 2023; 6: 31–37.
BERTASSO IM, et al. Low protein diet during lactation programs hepatic metabolism in adult male and female rats. Journal of Nutritional Biochemistry, 2022; 103: 109096.
BORGE TC, et al. The importance of maternal diet quality during pregnancy on cognitive and behavioural outcomes in children: a systematic review and meta-analysis. Journal of Food & Nutrition Research, 2017.
CHATTERJEE P, et al. Regulation of the anti-inflammatory cytokines interleukin-4 and interleukin-10 during pregnancy. Frontiers in Immunology, 2014; 5.
COELHO R, et al. The impact of cannabidiol treatment on anxiety disorders: a systematic review of randomized controlled clinical trials. Life, 2024; 14(11): e1373.
EL BP, et al. Nutrição durante a gravidez. Femina, 2020; 48(4): 245-256.
ELANGO R, BALL RO. Protein and amino acid requirements during pregnancy. Advances in Nutrition, 2016; 7: 83-95.
FELICIONI F. Implicações do consumo crônico de dieta hipoproteica durante a gestação sobre a foliculogênese, a morfologia placentária e suas consequências sobre a prole em camundongos heterogênicos. 2019. Tese (Doutorado em Biologia Celular) – Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Belo Horizonte, 2019.
GONTIJO ÉC, et al. Canabidiol e suas aplicações terapêuticas. Revista Eletrônica da Faculdade de Ceres, 2016; 5: 1.
GUO Y, et al. Maternal protein deficiency impairs peroxisome biogenesis and leads to oxidative stress and ferroptosis in liver of fetal growth restriction offspring. Journal of Nutritional Biochemistry, 2023; 121: 109432.
HERRING CM, et al. Impacts of maternal dietary protein intake on fetal survival, growth, and development. Experimental Biology and Medicine (Maywood), 2018; 243(6): 525-533.
JESUS B, et al. PANCs – Plantas Alimentícias Não Convencionais, benefícios nutricionais, potencial econômico e resgate da cultura: uma revisão sistemática. Enciclopédia Biosfera, 2020; 17: 33.
JI Y, et al. Fetal and neonatal programming of postnatal growth and feed efficiency in swine. Journal of Animal Science and Biotechnology, 2017; 8: 42.
LAGEMEAT MV, et al. Addressing nutritional needs in preterm infants to promote long-term health. In: Early Nutrition and Long-Term Health, 2022; 419-436.
LI XL, et al. Dietary supplementation with L-arginine between days 14 and 25 of gestation enhances embryonic development and survival in gilts. Amino Acids, 2014; 46: 375–384.
LUMBERS ER. et al. The lung, the heart, the novel coronavirus, and the renin-angiotensin system: the need for clinical trials. Frontiers in Medicine, 2020; 7: 248.
MARTINELLI SS, CAVALLI SB. Alimentação saudável e sustentável: uma revisão narrativa sobre desafios e perspectivas. Ciência & Saúde Coletiva, 2019; 24(11): 4251–4262.
MOHAMMED S, et al. A baixa proteína na dieta gestacional induz inflamação intrauterina e altera a programação da adiposidade e da sensibilidade à insulina na prole adulta. Journal of Nutritional Biochemistry, 2022.
NAKANO Y, et al. Development of a novel nano-emulsion formulation to improve intestinal absorption of cannabidiol. Medical Cannabis and Cannabinoids, 2019; 2(1): 35-42.
PALLADINO E, et al. Diet alters micronutrient pathways in the gut and placenta that regulate fetal growth and development in pregnant mice. Reproductive Sciences, 2021; 28: 447-461.
PEREIRA SR, et al. Cannabidiol modulation of oxidative stress and signalling. Neuronal Signaling, 2021; 5: eNS20200080.
PEREIRA TR, et al. Importância da educação alimentar e nutricional para alunos de séries iniciais. Lynx, 2020; 1: 1.
REEVES PG. Components of the AIN-93 diets as improvements in the AIN-76A diet. J Nutr., 1997.
ROMANOWSKA PK, et al. O papel do TNF-α e Anti-TNF-α agentes durante a pré-concepção, gravidez e amamentação. International Journal of Molecular Sciences, 2021; 22: 2922.
SANTOS AB, et al. Eficácia do canabidiol no tratamento de convulsões e doenças do sistema nervoso central: revisão sistemática. Acta Brasiliensis, 2019; 3(1): 30-34.
SAVITIKADI P, et al. Combined prenatal to postnatal protein restriction augments protein quality control processes and proteolysis in the muscle of rat offspring. Journal of Nutritional Biochemistry, 2023; 114: 109273.
SENE LB, et al. Impact of gestational low-protein intake on embryonic kidney microRNA expression and in nephron progenitor cells of the male fetus. PLoS ONE, 2021; 16(2): e0246289.
SILVA AJ, et al. Uso do canabidiol (Cannabis sativa L.) como possível forma de tratamento para doença trofoblástica gestacional associada a Mola Hidatiforme. Revista Eletrônica Acervo Saúde, 2024; 24(9): e17261.
SIMÕES-ALVES AC, et al. Diet enriched in saturated fatty acids induces liver oxidative stress and elicits inflammatory pathways prior to metabolic disruption in perinatal protein undernutrition. Nutrition Research, 2023; 118: 104–115.
ZHANG J, et al. The pharmacology and therapeutic role of cannabidiol in diabetes. Exploration (Beijing), 2023; 3(5): 20230047.