Palabras clave
Biopsia líquida
VPH
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Resumen
Objetivo: Evaluar la capacidad predictiva de una prueba de orina en pacientes con patologías vulvares, vaginales y cervicales inducidas por VPH. Métodos: Estudio prospectivo y descriptivo mediante análisis cuantitativo y cualitativo. Se evaluaron mujeres con diferentes diagnósticos mediante biopsia y prueba de orina. Resultados: Se seleccionaron 87 mujeres y se dividieron en cuatro grupos: grupo control (27,6%), grupo con condiloma acuminado (21,8%), grupo con lesión intraepitelial de bajo grado (21,8%) y grupo con lesión intraepitelial de alto grado (28,7%). Los resultados mostraron que la prueba de orina tuvo un valor predictivo del 78,7% en comparación con el estándar de oro, la biopsia. El grupo con lesión intraepitelial de alto grado mostró una concordancia perfecta con los resultados de la prueba de orina. Los genotipos de VPH identificados con mayor frecuencia fueron VPH16, seguido de VPH6, 52 y 53. Conclusión: La prueba de orina demostró ser valiosa para investigar el ADN del VPH, especialmente en el grupo con lesiones intraepiteliales de alto grado. Sin embargo, se necesita más investigación para ampliar el estudio y se deberían emplear estrategias adicionales para aumentar la adherencia de las mujeres.
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