Palabras clave
Estrés oxidativo
Glutatión
Especies reactivas de oxígeno
Evaluación nutricional
Cómo citar
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Resumen
Objetivo: Analizar biomarcadores de estrés oxidativo (EO), centrándose en el mecanismo del glutatión, después de un año en los mismos pacientes en hemodiálisis. Métodos: Estudio observacional y longitudinal realizado en una clínica de diálisis. Se analizaron glutatión reducido (GSH), glutatión oxidado (GSSG), cociente GSH:GSSG y glutatión peroxidasa (GPx). Para análisis, se utilizaron pruebas t de Student para muestras pareadas, prueba de Wilcoxon, prueba de chi-cuadrado y correlación de Pearson o Spearman. Los tamaños del efecto se calcularon mediante la g de Hedges y el delta de Cliff. Para el análisis retrospectivo de la potencia estadística, se utilizó el software G*Power®. P < 0,05 se consideró estadísticamente significativo. Resultados: Diez pacientes completaron el estudio. Tras un año, se observó aumento de GSSG (P = 0,000) y GPx (P = 0,041), así como disminución de GSH (p = 0,007) y del cociente GSH:GSSG (P = 0,000). Se encontraron correlaciones positivas moderadas, no significativas, entre tiempo en hemodiálisis y niveles de GSSG (rho = 0,4108, p = 0,5), y una correlación negativa moderada entre GSH (rho = -0,5817, p = 0,007) y el cociente GSH:GSSG (rho = -0,5123, p = 0,025). Conclusión: Hubo aumento significativo de EO relacionado con el mecanismo del glutatión.
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