Palabras clave
Dianas proteicas
Desarrollo de insecticidas
Dianas moleculares
Cómo citar
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Resumen
Objetivo: Identificar las principales proteínas de Aedes aegypti investigadas en el desarrollo de insecticidas. Métodos: Se realizó una revisión de la literatura científica publicada entre 2014 y 2024 utilizando las bases de datos PubMed, ScienceDirect y Scopus, con los descriptores "Aedes aegypti", "protein targets" y "mode of action". Se incluyeron artículos experimentales revisados por pares y publicados en inglés. Los estudios seleccionados se analizaron según los tipos de proteínas diana investigadas y los enfoques metodológicos utilizados (in silico, in vitro e in vivo). Resultados: De los 335 artículos recuperados inicialmente, 17 cumplieron los criterios de inclusión. El glutatión S-transferasa (GST) fue la diana de desintoxicación investigada con mayor frecuencia, seguida de varias isoformas de GST. Las dianas metabólicas clave incluyeron la proteína fijadora de olores 1 (OBP1), la 3-hidroxiquinurenina transaminasa (HKT), la acetilcolinesterasa (AChE), la proteína transportadora de esteroles 2 (SCP-2) y la anhidrasa carbónica (CA). Las dianas relacionadas con la neurotransmisión incluyeron el receptor dopaminérgico AaDOP2 y los cotransportadores de cationes cloruro CCC2 y CCC3. Conclusión: Los resultados destacan las dianas proteicas como una estrategia prometedora para el control de A. aegypti y enfatizan la necesidad de identificar nuevas dianas moleculares para insecticidas más eficaces y sostenibles.
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