Palabras clave
Flavonoides
Neurodegeneración
Terapias antioxidantes
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Resumen
Objetivo: Revisar sistemáticamente las evidencias científicas sobre el potencial neuroprotector de la polidatina y la quercetina en enfermedades neurodegenerativas. Métodos: Se trata de una revisión sistemática cualitativa y descriptiva, realizada en las bases de datos PubMed y SciELO, utilizando descriptores MeSH y DeCS combinados con operadores booleanos. Se incluyeron estudios publicados entre 2020 y 2025. Resultados: Se seleccionaron nueve estudios sobre la temática, de los cuales se extrajeron: el antioxidante, el título y el año de publicación, el objetivo, la metodología, el mecanismo de acción y la conclusión para la realización del análisis. Los resultados indican que la polidatina y la quercetina presentan actividades neuroprotectoras consideradas relevantes, actuando en la modulación de vías biológicas asociadas a la neurodegeneración y en la atenuación de los síntomas. Conclusión: Los datos analizados refuerzan que los antioxidantes son una alternativa prometedora, con una gama de actividades, no solo minimizando los síntomas de las enfermedades neurodegenerativas y los efectos secundarios causados por los fármacos actuales, sino también modulando los procesos biológicos que conducen a la neurodegeneración.
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