Keywords
Crohn’s disease
Ulcerative colitis
Anxiety
Depression
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Abstract
Objective: To assess possible or probable cases of anxiety and depression in patients with Inflammatory Bowel Diseases under outpatient follow-up at a university hospital in northeastern Brazil. Methods: An observational and cross-sectional study was conducted on a cohort of patients with Ulcerative Colitis (UC) and Crohn's Disease (CD) at a university hospital in northeastern Brazil. The Hospital Anxiety and Depression Scale (HADS) was used to evaluate anxiety and depression in these patients. Results: A total of 148 patients were included, with 58.1% having CD and 41.9% having UC, of which 87 (58.8%) were female, predominantly in the age group of 51 to 60 years, residing in urban areas, with disease activity in clinical remission, and an average disease duration of 10 years. The results indicated that 39 (45.3%) of the patients with CD and 24 (38.7%) of the patients with UC showed a risk score for anxiety classified as “possible” or “probable.” Additionally, 30 (34.9%) of the patients with CD and 14 (22.6%) of the patients with UC showed a risk score for depression classified as “possible” or “probable.” Conclusion: Inflammatory bowel diseases may affect the emotional status of patients and contribute to manifestations of anxiety and depression symptoms.
References
ABU SNEINEH A, et al. Prevalence of anxiety and depressive symptoms in ulcerative colitis patients in Jordan and its relationship to patient-reported disease activity. Scientific Reports, 2022; 12(1): 7682.
ANCELMO JGT, et al. O aumento da incidência de ansiedade e depressão em consequência da pandemia de Covid-19. Revista interdisciplinar em saúde, 2024; 11:19–30.
BALDERRAMO D, et al. Challenges in the diagnosis and treatment of inflammatory bowel disease in Latin America. The Lancet Gastroenterology & Hepatology, 2024; 9(3): 263-272.
BISGAARD TH, et al. Depression and anxiety in inflammatory bowel disease: epidemiology, mechanisms and treatment. Nature Reviews Gastroenterology & Hepatology, 2022; 19 (11): 717–726.
BRODERSEN JB, et al. Mo2007 Diagnostic Accuracy Of Magnetic Resonance Imaging Enterocolonography, Intestinal Ultrasound And Panenteric Capsule Endoscopy For Assessing Treatment Response In Known Crohn's Disease. Gastroenterology, 2024;166(5): 1192.
CHEEMA M, et al. Depression, anxiety and stress among patients with inflammatory bowel disease during the COVID-19 pandemic: Australian national survey. BMJ Open Gastroenterology, 2021; 8(1): 581.
CHRISTENSEN KR, et al. Identifying and understanding disease burden in patients with inflammatory bowel disease. BMJ Open Gastroenterology, 2022; 9(1): 994.
DUBINSKY MC, et al. Burden of comorbid anxiety and depression in patients with inflammatory bowel disease: a systematic literature review. Expert Review of Gastroenterology & Hepatology, 2021; 15(9): 985–997.
EUGENICOS MP e FERREIRA NB. Psychological factors associated with inflammatory bowel disease. British Medical Bulletin, 2021; 138(1): 16–28.
FALCÃO LTM e MARTINELLI VF. Associação de doença inflamatória intestinal com ansiedade e depressão: avaliação dos fatores de risco. GED Gastroenterologia Endoscopia Digestiva, 2016; 35(2): 52-58.
FARBOD Y, et al. Reduction in anxiety and depression scores associated with improvement in quality of life in patients with inflammatory bowel disease. Journal of the Canadian Association of Gastroenterology, 2022; 5(1): 12–17.
GAO X, et al. Sintomas de ansiedade/depressão estão associados a doença inflamatória intestinal mais agressiva. Sci Rep, 2021; 11: 1440.
KNYAZEV O, et al. P007 The frequency of anxiety and depression in patients with inflammatory bowel diseases in the Moscow clinical scientific center. American Journal of Gastroenterology, 2021; 116(1): 2.
LEE JW. Anxiety and depression in patients with inflammatory bowel diseases: The First Step Toward Proper Management. Gut and Liver, 2020; 14(4): 395–396.
MOULTON CD, et al. Depressive symptoms in inflammatory bowel disease: an extraintestinal manifestation of inflammation? Clinical and Experimental Immunology, 2019; 197(3): 308–318.
PARENTE JM, et al. Inflammatory bowel disease in an underdeveloped region of Northeastern Brazil. World Journal of Gastroenterology, 2015; 21 (4): 1197-1206.
PIOVANI D, et al. Association of depression with incident inflammatory bowel diseases: a systematic review and meta-analysis. Inflammatory Bowel Diseases, 2024; 4: 573–584.
QUEIROZ NSF, et al. IBD barriers across the continents: a continent-specific analysis: Latin America. Therapeutic Advances in Gastroenterology, 2023; 16(16).
RODA G, et al. Crohn’s disease. Nature Reviews Disease Primers, 2020; 6(1): 22-2.
SABERZADEH-ARDESTANIB B, et al. Clinical phenotype and disease course of inflammatory bowel disease in Iran: results of the Iranian registry of Crohn’s and Colitis (IRCC). Archives of Iranian Medicine, 2024; 27(4): 183–190.
SAEID SEYEDIAN S, et al. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease. Journal of Medicine and Life, 2019; 12(2): 113–122.
SALGADO VCL, et al. Risk factors associated with inflammatory bowel disease: a multicenter case-control study in Brazil. World J Gastroenterol, 2020; 26(25): 3611–3624.
SANTOS CHM, et al. Comparative analysis of anxiety and depression prevalence between individuals with and without inflammatory bowel disease. Journal of Coloproctology, 2020; 40(4): 339–344.
SCHAEUFFELE C, et al. The unified protocol as an internet-based intervention for emotional disorders: Randomized controlled trial. PLOS ONE, 2022; 17(7): 270178.
SINGH N e BERNSTEIN CN. Environmental risk factors for inflammatory bowel disease. United European Gastroenterology Journal, 2022; 10(10): 1047–1053.
STROIE T, et al. Anxiety and depression in patients with inactive inflammatory bowel disease: the role of fatigue and health-related quality of life. Medicine, 2023; 102(19): 33713.
VASSALLO R, et al. Clinical epidemiology of inflammatory bowel diseases in Brazil: a multicenter study. Journal of Crohn's and Colitis, 2020; 14(2): 258-266.
YU R, et al. Correlation analysis between disease activity and anxiety, depression, sleep disturbance, and quality of life in patients with inflammatory bowel disease. Nature and Science of Sleep, 2023; 15: 407–421.