Keywords
Women
Sex hormones
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Abstract
Objective: To analyze the relationship between the pathophysiology of migraine attacks women and female sex hormones, considering hormonal variations during different reproductive phases. Methods: This is an integrative review including articles published in english between 2014 and 2024. Searches were conducted in the Regional Portal of the Virtual Health Library (PR-BVS) and the National Library of Medicine (PubMed) databases, using the Health Sciences Descriptors (DeCS): “migraine”, “sex hormones” and “women”, combined with the Boolean operator “AND”. Results: 23 articles were included after applying inclusion and exclusion criteria. The analysis revealed that most studies discuss the relationship between fluctuations in female hormonal levels throughout the reproductive lifespan and pathogenesis of migraine. Conclusions: The higher prevalence of migraines in women appears to be associated with neuroendocrine factors and hormonal fluctuations that influence the pathophysiology of migraine episodes, highlighting the importance of potencial future therapeutic approaches.
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