Ora-pro-nóbis (Pereskia aculeata Mill.): characteristics, health evidence, and potential use as a dietary supplements

Abstract

Objective: To review the characteristics and applications of Ora-Pro-Nóbis (OPN) (Pereskia aculeata Mill.), highlighting evidence of health promotion related to its consumption, as well as clarifying the current regulatory scenario. Literature review: OPN is an Non-Conventional Food Plant (PANC) that is easy to cultivate and has high nutritional value due to its high concentrations of proteins, fibers, vitamins (A, C, and B9), and minerals (calcium, iron, magnesium, manganese, and zinc). Preclinical and clinical evidence associates its consumption with potential health benefits, including anti-obesity, antioxidant, anti-inflammatory, analgesic, and intestinal modulatory activities. Additionally, investigations indicate an enhancement of longevity, neuroprotective effects, and improvements in metabolic parameters. The traditional use of OPN in culinary practices and folk medicine is extensive. However, as of this date (Dec/2025), the Brazilian Health Regulatory Agency (Anvisa) prohibits its use as an ingredient in dietary supplements, restricting its consumption solely to traditional food forms. Final considerations: The hardiness and broad applications make OPN production a viable alternative capable of adding value for small-scale farmers. However, further studies, especially clinical trials, must be conducted to investigate its safety and potential health benefits, thereby rationalizing the benefits associated with OPN consumption.