Abstract
Objective: To identify the clinical and ventilatory criteria and strategies used in weaning newborns from invasive mechanical ventilation in a Neonatal Intensive Care Unit. Methods: This is an integrative review, conducted using the PubMed, SciELO, LILACS, Virtual Health Library, Scopus, and Web of Science databases, encompassing studies published between 2020 and 2025, in Portuguese and English. Studies were selected through reading titles, abstracts, and full texts. The methodological quality and level of evidence of the included publications were assessed using the GRADE system and the OCEBM hierarchy of evidence. Results: The final sample consisted of 9 studies. The findings indicated that standardized clinical and ventilatory criteria, associated with hemodynamic stability, adequate gas exchange, and the application of the spontaneous breathing trial, contribute to reducing the duration of mechanical ventilation and extubation failure rates. Final considerations: Scientific evidence indicates that the adoption of defined criteria and systematized strategies for neonatal ventilator weaning promotes patient safety and better clinical outcomes, supporting neonatal care practice.
References
ALCÂNTARA JCO. Um protocolo de ventilação mecânica neonatal de um hospital público. Revista Multidisciplinar da Saúde, 2023;5(1): 49–61.
ALMEIDA SC. Protocolo de desmame para redução do tempo de ventilação mecânica em crianças internadas em Unidades de Terapia Intensiva Pediátrica: revisão sistemática e metanálise. 2024. Dissertação (Pós-graduação em Fisioterapia) – Universidade Federal de Uberlândia, Uberlândia, 2024.
AMARAL JQ, et al. Atuação fisioterapêutica em unidades de terapia intensiva neonatal do Rio Grande do Sul. Fisioterapia Pesquisa, 2022; 29(4): 350-356.
BACCI SLLS, et al. Mechanical ventilation weaning practices in neonatal and pediatric ICUs in Brazil: the weaning survey-Brazil. Jornal Brasileiro de Pneumologia, 2020; 46(1).
BICKENBACH J, et al. Effects of structured protocolized physical therapy on the duration of mechanical ventilation in patients with prolonged weaning. J Crit Care. 2024;80:154491.
CALEGARI LH, et al. Predictors and outcomes of extubation failure in preterm neonates: a systematic review. Pediatrics. 2025;155(2):e2024068677.
COSTA TP, OLIVEIRA AA. Importância da fisioterapia na reversão de atelectasias em recém-nascidos pré-termo dentro da Unidade de Terapia Intensiva Neonatal. Brazilian Journal of Implantology and Health Sciences, 2023; 5(5): 4130–4141.
ESPÍNDOLA CS, et al. Fatores associados ao uso de oxigenoterapia e suporte ventilatório em recém-nascidos prematuros. Revista Pesquisa em Fisioterapia, 2022; 12.
GRADE WORKING GROUP. Grading of Recommendations Assessment, Development and Evaluation (GRADE). 2013.
OXFORD CENTRE FOR EVIDENCE-BASED MEDICINE. Levels of evidence. Oxford, 2011.
ROSSETTI TC. Falha de extubação em recém-nascidos internados na unidade de terapia intensiva neonatal em um hospital universitário. Ensaios UFS, 2020; 4(2): 1–11.
SANGSARI R, et al. Weaning and extubation from neonatal mechanical ventilation: an evidence-based review. BMC Pulmonary Medicine, 2022; 22: 1–12.
SHALISH W, et al. Assessment of extubation readiness using spontaneous breathing trials in extremely preterm neonates. JAMA Pediatrics, 2020; 174(2): 178–185.
SOUZA AJS, et al. O processo de desmame da ventilação mecânica no paciente neonato. Revista Artigos.com, 2020; 18: e4055.
SOUZA BC. Desmame ventilatório em recém-nascidos prematuros: avaliação do TRE com método CPAP-PS. 2023. Dissertação (Pós-graduação em Ciências da Reabilitação) – Centro Universitário Augusto Motta, Rio de Janeiro, 2023.
TEIXEIRA RF, et al. Spontaneous breathing trials in preterm infants: systematic review and meta-analysis. Respiratory Care, 2021a; 66(1): 129–137.
TEIXEIRA RF, et al. Factors associated with extubation failure in very low birth weight infants. Journal of Perinatal Medicine, 2021b; 49(4): 506–513.
TELIAS I, et al. The physiological underpinnings of life-saving respiratory support. Intensive Care Medicine, 2022; 48: 1274–1286.
VITTI JD, et al. Use of noninvasive mechanical ventilation weaning protocol in neonatal intensive care units in Brazil: a descriptive study. Revista Paulista de Pediatria, 2023; 41.
ZHANG H, et al. A nomogram to predict extubation failure in infants born before 32 gestational weeks: a single center retrospective study. Transl Pediatr. 2025;14(5):776 787.
