Keywords
Pre-exposure prophylaxis
Pharmaceutical services
Pharmaceutical care
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Abstract
Objective: To map Pre-Exposure Prophylaxis (PrEP) strategies for HIV in higher-vulnerability populations and to identify the role of pharmacists in access and adherence. Methods: A scoping review conducted according to the Joanna Briggs Institute (JBI) guidelines, using the PCC acronym (Participants: PrEP distribution/dispensing services; Concept: HIV Pre-exposure Prophylaxis; Context: vulnerable populations). Searches were performed in Lilacs, PubMed, SciELO, Cochrane, JBI Evidence Synthesis, ScienceDirect, CAPES, and Google Scholar, from 2021 to 2026. Studies were managed using Mendeley® and selected through Rayyan®. Results: Nineteen articles were included. Most had a very low level of evidence (57.9%). Only 3 studies (15.7%) addressed the pharmacist's role, highlighting a literature gap. Socioeconomic factors, stigma, education, and race were the main determinants of PrEP access and adherence. Final considerations: PrEP is an effective strategy, but structural and social barriers limit its reach in vulnerable populations. Pharmaceutical care is promising but underexplored, requiring more robust studies and inclusive public policies.
References
ALEXANDRE HO, et al. HIV pre-exposure prophylaxis in Latin America: public policies, healthcare systems and human rights. Prev Med Rep, 2025; 54: 103070.
AROMATARIS E, MUNN Z, editors. JBI manual for evidence synthesis [Internet]. Adelaide: JBI; 2020.
CAMBIANO V, et al. The effect of combination prevention strategies on HIV incidence among gay and bisexual men who have sex with men in the UK: a model-based analysis. Lancet HIV, 2023; 10(11): e713-e722.
CHAVES JC, et al. Intervenções farmacêuticas e seus desfechos em portadores de HIV/AIDS em atendimento de média complexidade. Rev Eletron Acervo Saude, 2021; 13(4): e4390.
CORDEIRO L, SOARES CB. Revisão de escopo: potencialidades para a síntese de metodologias utilizadas em pesquisa primária qualitativa. BIS, Bol Inst Saúde, 2019; (Número Especial): 37-42.
CRAWFORD ND, et al. Feasibility of reaching populations at high risk for HIV in community pharmacies. J Am Pharm Assoc (2003), 2024; 64(6): 102239.
CRITICAL APPRAISAL SKILLS PROGRAMME. CASP checklist: 10 questions to help you make sense of qualitative research [Internet]. Oxford: CASP; 2018.
GAN YN, et al. Development and evaluation of an online HIV pre-exposure prophylaxis (PrEP) training program for community pharmacists to implement pharmacy-led PrEP services in Malaysia. PLoS One, 2025; 20(8): e0328713.
HARRISON C, et al. Qualitative exploration of the barriers and facilitators to community pharmacy PrEP delivery for UK pharmacists and underserved community members using the COM-B model of behaviour change. Sex Transm Infect, 2024; 100: 1-8.
HAYNES AS, et al. A systematic review and narrative synthesis of factors affecting pre-exposure prophylaxis willingness among Black women for HIV prevention. AIDS Behav, 2025; 29: 101-132.
HUDRUDCHAI S, et al. Pre-exposure prophylaxis adherence among men who have sex with men: a systematic review and meta-analysis. J Prev Med Public Health, 2024; 57: 8-17.
JAISWAL J, et al. PrEP-related medical, structural and institutional mistrust among a socioeconomically diverse sample of Black, Latine, Asian, and White young sexual minority men: lived experiences of intersectional inequity. AIDS Behav, 2026; 30: 440-453.
JALIL EM, et al. Low PrEP adherence despite high retention among transgender women in Brazil: the PrEParadas study. J Int AIDS Soc, 2022; 25: e25896.
MARCUS U, et al. Analysis of HIV pre-exposure prophylaxis (PrEP) needs and PrEP use in Germany among men who have sex with men. J Public Health, 2022; [volume e páginas a definir – verifique na publicação final].
MINISTÉRIO DA SAÚDE (BR). Relatório de implantação PrEP HIV: jan-dez 2018. Brasília, DF: Ministério da Saúde; 2019.
MINISTÉRIO DA SAÚDE (BR). Boletim epidemiológico HIV/Aids 2024: número especial. Brasília, DF: Ministério da Saúde; 2024.
MINISTÉRIO DA SAÚDE (BR). Secretaria de Vigilância em Saúde. Protocolo clínico e diretrizes terapêuticas para profilaxia pré-exposição (PrEP) de risco à infecção pelo HIV, infecções sexualmente transmissíveis e hepatites virais. Brasília, DF: Ministério da Saúde; 2025.
MINISTÉRIO DA SAÚDE (BR). Sistema de Controle Logístico de Medicamentos (SICLOM) [Internet]. Brasília, DF: Ministério da Saúde; 2025. Disponível em: https://siclom.aids.gov.br/. Acesso em: 23 maio 2026.
MONTEIRO, PVA, et al. Uso da profilaxia pré-exposição ao HIV entre homens gays e outros homens que fazem sexo com homens.. Escola Anna Nery, 2024; 28: e20240093, 2024.
MURAD MH, et al. New evidence pyramid. Evid Based Med, 2016; 21(4): 125-127.
OMENOBA TC, et al. Expanding HIV prevention: exploring community pharmacists' willingness to provide PrEP in Nigeria. AIDS Behav, 2026; 30: 778-787.
O'NEILL J, et al. Applying an equity lens to interventions: using PROGRESS ensures consideration of socially stratifying factors to illuminate inequities in health. J Clin Epidemiol, 2014; 67(1): 56-64.
PETERS MDJ, et al. Scoping reviews. In: AROMATARIS E, MUNN Z, editors. JBI manual for evidence synthesis [Internet]. Adelaide: JBI; 2024.
SEPODES B, et al. Implementation and access to pre-exposure prophylaxis for human immunodeficiency virus by men who have sex with men in Europe. Front Med, 2021; 8: 722247.
SIQUEIRA CG, et al. Rastreamento de infecções sexualmente transmissíveis em pessoas não grávidas assintomáticas pertencentes a populações mais vulnerabilizadas: uma revisão de escopo rápida. Rev Panam Salud Publica, 2025; 49: e113.
SKOVDAL M, et al. Improving access to pre-exposure prophylaxis for adolescent girls and young women: recommendations from healthcare providers in eastern Zimbabwe. BMC Infect Dis, 2022; 22: 399.
SULLIVAN PS, et al. Estimating HIV incident diagnoses among men who have sex with men eligible for pre-exposure prophylaxis but not taking it: protocol and feasibility assessment of data sources and methods. JMIR Res Protoc, 2023; 12: e42267.
TIGUMAN GMB, et al. Role of pharmacists in HIV prophylaxis: a scoping review of pharmacists' services, interventions and outcomes. J Int AIDS Soc, 2026; 29: e70090.
TRICCO AC, et al. PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation. Ann Intern Med, 2018; 169(7): 467-473.
VAN DEN ELSHOUT MAM, et al. Sexual behaviour and incidence of sexually transmitted infections among men who have sex with men using daily and event-driven pre-exposure prophylaxis (PrEP): four-year follow-up of the Amsterdam PrEP demonstration project cohort. PLoS Med, 2024; 21(5): e1004328.